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Table 3 Numbers of microRNAs (out of the indicated numbers considered multimodal at each site) classified with respect to the tumor-normal test of differential expression as: (b, “blue”) overall significant, with significant directional agreement in one factor level and NS in the other; (g, “green”) overall NS, but significant in only one factor level; (o, “orange”) overall NS, and significant in opposite directions for factor levels; and (y, “yellow”) overall significant, with significant directional agreement in one factor level but significant in the opposite direction in the other factor level

From: Identifying factors associated with the direction and significance of microRNA tumor-normal expression differences in colorectal cancer

  Proximal (of 122) Distal (of 123) Rectal (of 276)
Factor b g o y b g o y b g o y
MSI 27    1 62    1 186    4
CIMP 19    1 29     64 1   
BRAF 13 3   1 58     176    
TP53 16     10     28 5   
KRAS 21 2    14     29 3 1  
STAGE_D 32 1    12 1    53 2   
STAGE_L 23     10     19 3 1  
STAGE_R 19     15     21 1   
AJCC_1 40 2    7 1    19 3   
AJCC_2 18     10     16 2 1  
AJCC_3 28 2    8 1    41 6   
SEX 23 3    6     12 1   
DIFF_NA 55     42        
DIFF_WELL 37     30        
DIFF_MOD 13     16        
DIFF_POOR 21 1    27        
VITAL_ALIVE 16     15 5    27 1   
SURV5YRS 17     21 4 2   18 1   
COD_CRC 19 1    3 6    67 9   
ALCOHOL_reg 11     7     51 5   
WINE_any 9 1    12 1    78 8 1 1
LIQUOR_any 13 1    14 3    68 5 1 1
BEER_any 16 2    11     56 2   
CIG_ever 24 5    4     36 5   
CIG_current 23     17 1    69 8 1  
CIG_former 19 4    5     28 1   
ESTROGEN 12 1    11     46 4   
BMI_normal 9     10 2    33 4   
BMI_overweight 17 4    10     30 1   
BMI_obese 18     22     68 2   
BMI_extreme 66     58     150 1