Table 1 Summary of subject-level factors considered for association with direction of tumor-normal microRNA differential expression

MSI: MSI (0 = stable / MSS, 1 = unstable / MSI)

428

128

11

508

23

19

699

16

4

CIMP: CIMP status (0 = low, 1 = high)

280

204

83

403

63

84

599

76

44

BRAF: BRAF mutation status (0 = none, 1 = mutation)

391

73

103

433

15

102

685

19

15

TP53: TP53 mutation status (0 = none, 1 = mutation)

325

222

20

255

265

30

344

353

22

KRAS: KRAS mutation status (0 = none, 1 = mutation)

341

198

28

364

141

45

502

212

5

STAGE_D: SEER summary stage distant (0 = no, 1 = yes)

475

92

0

459

91

0

632

87

0

STAGE_L: SEER summary stage local (0 = no, 1 = yes)

417

150

0

365

185

0

393

326

0

STAGE_R: SEER summary stage regional (0 = no, 1 = yes)

252

315

0

293

257

0

431

288

0

AJCC_1: AJCC stage 1 (0 = no, 1 = yes)

479

88

0

404

146

0

450

269

0

AJCC_2: AJCC stage 1 or 2 (0 = no, 1 = yes)

285

282

0

254

296

0

313

406

0

AJCC_3: AJCC stage 1, 2, or 3 (0 = no [stage 4], 1 = yes)

102

465

0

106

444

0

111

608

0

SEX: 1 = male, 0 = female

286

281

0

300

250

0

409

310

0

DIFF_NA: Tumor differentiation n/a (0 = no, 1 = yes)

242

24

301

508

40

2

0

719

0

DIFF_WELL: Tumor differentiation well (0 = no, 1 = yes)

516

50

1

491

57

2

719

0

0

DIFF_MOD: Tumor differentiation moderate (0 = no, 1 = yes)

199

367

1

161

387

2

719

0

0

DIFF_POOR: Tumor differentiation poor (0 = no, 1 = yes)

441

125

1

484

64

2

719

0

0

VITAL_ALIVE: Vital status at last follow-up (0 = dead, 1 = alive)

281

285

1

261

288

1

341

378

0

SURV5YRS: Survival at least 60 months after sample taken (0 = no, 1 = yes)

257

309

1

233

316

1

297

422

0

COD_CRC: Cause of death CRC (0 = no, 1 = yes)

81

179

307

70

160

320

112

229

378

ALCOHOL_reg: Referent year alcohol consumption at least 1.0 g/day (0 = no, 1 = yes)

247

198

122

243

175

132

292

246

181

WINE_any: More than 0 4 oz. glasses wine per day (0 = no, 1 = yes) during referent year

303

142

122

284

134

132

385

153

181

LIQUOR_any: More than 0 servings liquor per day (0 = no, 1 = yes) during referent year

326

119

122

301

117

132

421

117

181

BEER_any: More than 0 servings beer per day (0 = no, 1 = yes) during referent year

327

118

122

317

101

132

374

164

181

CIG_ever: Ever smoked cigarettes (0 = no, 1 = yes)

180

264

123

183

234

133

239

299

181

CIG_current: Current smoker (0 = no, 1 = yes)

377

67

123

360

57

133

448

90

181

CIG_former: Former smoker (0 = no, 1 = yes)

247

197

123

240

177

133

341

197

181

ESTROGEN: Estrogen exposure within past 2 years (0 = no, 1 = yes; missing for all males)

133

69

365

112

72

366

119

108

492

BMI_normal: BMI [“for analysis 2 years ago”] less than 25 (0 = no, 1 = yes)

299

144

124

270

143

137

355

179

185

BMI_overweight: BMI at least 25 and less than 30 (0 = no, 1 = yes)

249

194

124

258

155

137

344

190

185

BMI_obese: BMI at least 30 and less than 40 (0 = no, 1 = yes)

355

88

124

310

103

137

390

144

185

BMI_extreme: BMI at least 40 (0 = no, 1 = yes)

426

17

124

401

12

137

513

21

185