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Table 1 Summary of subject-level factors considered for association with direction of tumor-normal microRNA differential expression

From: Identifying factors associated with the direction and significance of microRNA tumor-normal expression differences in colorectal cancer

  Proximal (N = 567) Distal (N = 550) Rectal (N = 719)
Factor: Interpretation N0 N1 Nmiss N0 N1 Nmiss N0 N1 Nmiss
MSI: MSI (0 = stable / MSS, 1 = unstable / MSI) 428 128 11 508 23 19 699 16 4
CIMP: CIMP status (0 = low, 1 = high) 280 204 83 403 63 84 599 76 44
BRAF: BRAF mutation status (0 = none, 1 = mutation) 391 73 103 433 15 102 685 19 15
TP53: TP53 mutation status (0 = none, 1 = mutation) 325 222 20 255 265 30 344 353 22
KRAS: KRAS mutation status (0 = none, 1 = mutation) 341 198 28 364 141 45 502 212 5
STAGE_D: SEER summary stage distant (0 = no, 1 = yes) 475 92 0 459 91 0 632 87 0
STAGE_L: SEER summary stage local (0 = no, 1 = yes) 417 150 0 365 185 0 393 326 0
STAGE_R: SEER summary stage regional (0 = no, 1 = yes) 252 315 0 293 257 0 431 288 0
AJCC_1: AJCC stage 1 (0 = no, 1 = yes) 479 88 0 404 146 0 450 269 0
AJCC_2: AJCC stage 1 or 2 (0 = no, 1 = yes) 285 282 0 254 296 0 313 406 0
AJCC_3: AJCC stage 1, 2, or 3 (0 = no [stage 4], 1 = yes) 102 465 0 106 444 0 111 608 0
SEX: 1 = male, 0 = female 286 281 0 300 250 0 409 310 0
DIFF_NA: Tumor differentiation n/a (0 = no, 1 = yes) 242 24 301 508 40 2 0 719 0
DIFF_WELL: Tumor differentiation well (0 = no, 1 = yes) 516 50 1 491 57 2 719 0 0
DIFF_MOD: Tumor differentiation moderate (0 = no, 1 = yes) 199 367 1 161 387 2 719 0 0
DIFF_POOR: Tumor differentiation poor (0 = no, 1 = yes) 441 125 1 484 64 2 719 0 0
VITAL_ALIVE: Vital status at last follow-up (0 = dead, 1 = alive) 281 285 1 261 288 1 341 378 0
SURV5YRS: Survival at least 60 months after sample taken (0 = no, 1 = yes) 257 309 1 233 316 1 297 422 0
COD_CRC: Cause of death CRC (0 = no, 1 = yes) 81 179 307 70 160 320 112 229 378
ALCOHOL_reg: Referent year alcohol consumption at least 1.0 g/day (0 = no, 1 = yes) 247 198 122 243 175 132 292 246 181
WINE_any: More than 0 4 oz. glasses wine per day (0 = no, 1 = yes) during referent year 303 142 122 284 134 132 385 153 181
LIQUOR_any: More than 0 servings liquor per day (0 = no, 1 = yes) during referent year 326 119 122 301 117 132 421 117 181
BEER_any: More than 0 servings beer per day (0 = no, 1 = yes) during referent year 327 118 122 317 101 132 374 164 181
CIG_ever: Ever smoked cigarettes (0 = no, 1 = yes) 180 264 123 183 234 133 239 299 181
CIG_current: Current smoker (0 = no, 1 = yes) 377 67 123 360 57 133 448 90 181
CIG_former: Former smoker (0 = no, 1 = yes) 247 197 123 240 177 133 341 197 181
ESTROGEN: Estrogen exposure within past 2 years (0 = no, 1 = yes; missing for all males) 133 69 365 112 72 366 119 108 492
BMI_normal: BMI [“for analysis 2 years ago”] less than 25 (0 = no, 1 = yes) 299 144 124 270 143 137 355 179 185
BMI_overweight: BMI at least 25 and less than 30 (0 = no, 1 = yes) 249 194 124 258 155 137 344 190 185
BMI_obese: BMI at least 30 and less than 40 (0 = no, 1 = yes) 355 88 124 310 103 137 390 144 185
BMI_extreme: BMI at least 40 (0 = no, 1 = yes) 426 17 124 401 12 137 513 21 185
  1. All factors were coded 0/1, and corresponding sample sizes in proximal, distal, and rectal sites are indicated by N0 and N1. Missing values in some factors result in differences (Nmiss) between overall subject totals (N) and the sum of N0 + N1