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Table 3 Probability of overall survival and disease-free survival at 5 and 10 years according to the demographic, clinical and pathological variables of sporadic colorectal cancer patients

From: Oestrogen receptor beta isoform expression in sporadic colorectal cancer, familial adenomatous polyposis and progressive stages of colorectal cancer

Variable Overall survival (%) p Disease-free survival (%) p
5-y 10-y 5-y 10-y  
Survival 83.9 77.1 77.4 77.4
Gender
 Male 88.3 79.5 0.220 77.6 77.6 0.952
 Female 78.3 71.8 77.3 77.3
Age group (years)
  < 65 79.1 72.5 0.248 68.8 68.8 0.039
  ≥ 65 88.9 82.1 86.7 86.7
Topography
 Colon 83.3 74.4 0.430 75.7 75.7 0.403
 Upper rectal 86.7 86.7 86.7 86.7
CEA
 Normal (<5.0) 90.0 84.0 0.03 83.9 83.9 0.014
 Increased (>5.0) 66.8 58.5 59.4 59.4
T stage
 T1-T2 95.7 95.7 <0.001 97.9 97.9 <0.001
 T3-T4 72.1 40.1 56.7 56.7
N stage
 N0 94.9 94.9 <0.001 91.2 91.2 <0.001
 N+ 66.6 35.5 55.8 55.8
M stage
 M0 90.1 90.1 <0.001 86.1 86.1 <0.001
 M+ 49.0 0 28.6 28.6
Histological grade
 Well differentiated 87.5 12.5 0.126 87.5 87.5 0.026
 Moderately differentiated 53.3 0 78.8 78.2
 Poorly differentiated 0 0 40.0 40.0
Blood embolization
 No 85.6 78.6 0.002 80.0 80.0 <0.001
 Yes 33.3 0   0 0
Lymphatic embolization
 No 85.1 60.3 0.151 80.3 80.3 0.079
 Yes 76.9 0 58.3 58.3
Perineural invasion
 No 84.6 84.6 0.032 79.8 79.8 0.108
 Yes 0 0 55.6 55.6
KRAS
 Wild 79.8 79.8 0.310 74.2 74.2 0.710
 Mutated 61.9 61.9 66.7 66.7
Primer Pair 1- ERβ1, ERβ2 and ERβ4 isoforms*
  > −7.2   76.4 76.4 0.301
  ≤ −7.2   100 100
  > −3.2 87.5 87.5 0.361
  ≤ −3.2 82.7 73.5  
Primer Pair 2 - ERβ1 and ERβ5 isoforms*
  > −4.5   62.5 62.5 0.012
  ≤ −4.5   85.3 85.3
  > −7.6 81.6 81.6 0.118
  ≤ −7.6 100 100  
Primer Pair 3 - ERβ 2 isoform*
  > −4.5   76.8 76.8 0.609
  ≤ −4.5   85.7 85.7
  > −3.2 82.4 75.2 0.187
  ≤ −3.2 100 100  
  1. p-value obtained by the log-rank test. Statistically significant p values (p < 0.05) are shown in bold type. *The cut-off for relative gene expression (log2) was determined using the log-rank test (maximally selected rank statistics in R) [24]