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Table 3 Probability of overall survival and disease-free survival at 5 and 10 years according to the demographic, clinical and pathological variables of sporadic colorectal cancer patients

From: Oestrogen receptor beta isoform expression in sporadic colorectal cancer, familial adenomatous polyposis and progressive stages of colorectal cancer

Variable

Overall survival (%)

p

Disease-free survival (%)

p

5-y

10-y

5-y

10-y

 

Survival

83.9

77.1

77.4

77.4

Gender

 Male

88.3

79.5

0.220

77.6

77.6

0.952

 Female

78.3

71.8

77.3

77.3

Age group (years)

  < 65

79.1

72.5

0.248

68.8

68.8

0.039

  ≥ 65

88.9

82.1

86.7

86.7

Topography

 Colon

83.3

74.4

0.430

75.7

75.7

0.403

 Upper rectal

86.7

86.7

86.7

86.7

CEA

 Normal (<5.0)

90.0

84.0

0.03

83.9

83.9

0.014

 Increased (>5.0)

66.8

58.5

59.4

59.4

T stage

 T1-T2

95.7

95.7

<0.001

97.9

97.9

<0.001

 T3-T4

72.1

40.1

56.7

56.7

N stage

 N0

94.9

94.9

<0.001

91.2

91.2

<0.001

 N+

66.6

35.5

55.8

55.8

M stage

 M0

90.1

90.1

<0.001

86.1

86.1

<0.001

 M+

49.0

0

28.6

28.6

Histological grade

 Well differentiated

87.5

12.5

0.126

87.5

87.5

0.026

 Moderately differentiated

53.3

0

78.8

78.2

 Poorly differentiated

0

0

40.0

40.0

Blood embolization

 No

85.6

78.6

0.002

80.0

80.0

<0.001

 Yes

33.3

0

 

0

0

Lymphatic embolization

 No

85.1

60.3

0.151

80.3

80.3

0.079

 Yes

76.9

0

58.3

58.3

Perineural invasion

 No

84.6

84.6

0.032

79.8

79.8

0.108

 Yes

0

0

55.6

55.6

KRAS

 Wild

79.8

79.8

0.310

74.2

74.2

0.710

 Mutated

61.9

61.9

66.7

66.7

Primer Pair 1- ERβ1, ERβ2 and ERβ4 isoforms*

  > −7.2

 

76.4

76.4

0.301

  ≤ −7.2

 

100

100

  > −3.2

87.5

87.5

0.361

  ≤ −3.2

82.7

73.5

 

Primer Pair 2 - ERβ1 and ERβ5 isoforms*

  > −4.5

 

62.5

62.5

0.012

  ≤ −4.5

 

85.3

85.3

  > −7.6

81.6

81.6

0.118

  ≤ −7.6

100

100

 

Primer Pair 3 - ERβ 2 isoform*

  > −4.5

 

76.8

76.8

0.609

  ≤ −4.5

 

85.7

85.7

  > −3.2

82.4

75.2

0.187

  ≤ −3.2

100

100

 

  1. p-value obtained by the log-rank test. Statistically significant p values (p < 0.05) are shown in bold type. *The cut-off for relative gene expression (log2) was determined using the log-rank test (maximally selected rank statistics in R) [24]