Fig. 2

a ESR2 expression levels in sporadic CRC, sporadic polyps and FAP polyps in comparison to normal tissues according to the type of tissue (fresh frozen tissues: superior graphics or FFPE: inferior graphics). b Comparison of ESR2 expression levels in normal and sporadic colorectal cancer of TCGA database (log2 + 1 from RNA sequencing read per million values). c The samples were grouped into two T stages using the TNM classification (T1/T2 vs T3/T4) with relative expression of the ESR2 isoforms. NS = Sporadic normal mucosa; SP = Sporadic polyps; ST = Sporadic tumour; NFAP = Normal mucosa FAP; PFAP = Polyp FAP; TCGA = The Cancer Genome Atlas level 3) *: p < 0.05; **: p < 0.01; ***: p < 0.001; (Tukey’s Multiple Comparison Test and Student’s t-test)