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Table 4 Positive Predictive Values (PPV) of self-reported breast cancer characteristics stratified by age at diagnosis, Sister Study 2003-2014a

From: Validity of self-reported breast cancer characteristics in a nationwide cohort of women with a family history of breast cancer

  35–54 (n = 536) 55–64 (n = 744) ≥65 (n = 728)
Breast cancer characteristic Medical record (%)b Self-report (%)b PPV (%) Medical record (%)b Self-report      (%)b PPV (%) Medical record (%)b Self-report   (%)b PPV (%)
Invasiveness
 Invasive 396 (74) 340 (65) 99.4 554 (75) 448 (63) 99.3 583 (80) 403 (60) 99.3
 In situ 139 (26) 181 (35) 75.1 188 (25) 263 (37) 69.7 145 (20) 267 (40) 51.3
 Unknown 1 15   2 33   0 58  
Locationc
 Ductal (any) 467 (88) 426 (85) 98.6 669 (90) 586 (88) 99.1 668 (92) 550 (90) 98.9
 Lobular only 64 (12) 76 (15) 76.0 71 (10) 78 (12) 76.9 55 (8) 61 (10) 73.8
 Unknown 3 32   2 78   4 116  
Stage
 0 139 (26) 159 (32) 78.0 187 (25) 214 (33) 75.5 145 (20) 190 (31) 60.5
 I 241 (45) 183 (37) 92.8 367 (50) 258 (39) 91.9 427 (59) 271 (45) 91.9
 II 116 (22) 114 (23) 71.1 141 (19) 134 (20) 67.2 123 (17) 104 (17) 65.4
 III/IV 38 (7) 37 (8) 75.7 46 (6) 52 (8) 73.1 33 (5) 39 (6) 64.1
 Unknown 2 43   3 86   0 124  
Among medically confirmed invasive cases:d
 ER
  Positive 322 (84) 305 (81) 98.7 454 (83) 406 (82) 99.0 501 (89) 393 (85) 99.5
  Negative 63 (16) 73 (19) 82.6 90 (17) 92 (18) 87.6 64 (11) 69 (15) 77.3
  Unknown 11 18   10 56   18 121  
 PR
  Positive 293 (76) 207 (65) 99.5 375 (69) 213 (57) 99.1 413 (74) 223 (64) 98.2
  Negative 91 (24) 112 (35) 69.7 166 (31) 163 (43) 72.0 147 (26) 127 (36) 73.0
  Unknown 12 77   13 178   23 233  
 HER2
  Positive 49 (13) 64 (20) 71.7 65 (12) 90 (23) 67.0 53 (10) 78 (22) 60.0
  Negative 324 (87) 263 (80) 98.0 458 (88) 310 (78) 100 490 (90) 272 (78) 99.2
  Unknown 23 69   31 154   40 233  
  1. Abbreviation: PPV positive predictive value, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2
  2. aExcludes 43 who did not complete the questionnaire about breast cancer characteristics and 3 who reported on a different breast cancer event than the one abstracted from her medical records
  3. bData are reported as number (percentage) of women. Totals may not always equal 100% because of rounding
  4. cExcludes 5 cases that are not of ductal or lobular origin (phyllodes tumors)
  5. dER, PR, and HER2 analyses are restricted to 1533 cases (35–54: n = 396; 55–64: n = 554; ≥65: n = 583) confirmed as invasive breast cancer by medical records