Validity of self-reported breast cancer characteristics in a nationwide cohort of women with a family history of breast cancer

Table 3 Positive Predictive Values (PPV) of self-reported breast cancer characteristics stratified by race/ethnicity, Sister Study 2003-2014^a

	Non-Hispanic white (n = 1774)			Non-Hispanic black (n = 111)			Hispanic (n = 66)
Breast cancer characteristic	Medical record (%)^b	Self-report (%)^b	PPV (%)	Medical record (%)^b	Self-report (%)^b	PPV (%)	Medical record (%)^b	Self-report (%)^b	PPV (%)
Invasiveness
Invasive	1360 (77)	1074 (64)	99.3	77 (70)	48 (48)	100	51 (77)	32 (53)	100
In situ	412 (23)	615 (36)	65.3	33 (30)	51 (52)	62.7	15 (23)	28 (47)	46.4
Unknown	2	85		1	12		0	6
Location^c
Ductal (any)	1586 (90)	1380 (88)	99.0	106 (96)	87 (92)	100	60 (91)	47 (85)	97.9
Lobular only	175 (10)	196 (12)	77.0	4 (4)	8 (8)	42.9	6 (9)	8 (15)	62.5
Unknown	8	193		1	16		0	11
Stage
0	411 (23)	488 (31)	72.2	33 (30)	39 (40)	71.8	15 (23)	20 (38)	50.0
I	924 (52)	654 (42)	92.6	47 (43)	31 (32)	83.3	34 (52)	15 (29)	86.7
II	333 (19)	317 (20)	68.8	23 (21)	17 (17)	64.7	15 (23)	10 (19)	60.0
III/IV	102 (6)	102 (7)	75.5	7 (6)	11 (11)	54.5	2 (3)	7 (13)	28.6
Unknown	4	213		1	13		0	14
Among medically confirmed invasive cases:^d
ER
Positive	1147 (87)	1011 (84)	99.5	55 (71)	38 (64)	94.7	43 (90)	31 (79)	96.8
Negative	179 (13)	196 (16)	85.6	22 (29)	21 (36)	71.4	5 (10)	8 (21)	50.0
Unknown	34	153		0	18		3	12
PR
Positive	983 (75)	602 (64)	99.2	42 (55)	18 (40)	94.4	29 (62)	13 (45)	100
Negative	335 (25)	342 (36)	71.4	35 (45)	27 (60)	74.1	18 (38)	16 (55)	66.7
Unknown	42	416		0	32		4	22
HER2
Positive	144 (11)	203 (21)	64.7	6 (8)	11 (24)	54.5	9 (19)	7 (26)	100
Negative	1129 (89)	772 (79)	99.1	69 (92)	35 (76)	100	39 (81)	20 (74)	100
Unknown	87	385		2	31		3	24

Abbreviation: PPV positive predictive value, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2
^aExcludes 43 who did not complete the questionnaire about breast cancer characteristics and 3 who reported on a different breast cancer event than the one abstracted from her medical records and excludes 56 who reported other race/ethnicity and 1 with missing data for race/ethnicity
^bData are reported as number (percentage) of women. Totals may not always equal 100% because of rounding
^cExcludes 5 cases that are not of ductal or lobular origin (phyllodes tumors)
^dER, PR, and HER2 analyses are restricted to 1360 non-Hispanic white, 77 non-Hispanic black, and 51 Hispanic cases confirmed as invasive breast cancer by medical records

ISSN: 1471-2407