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Table 3 Association of lymphatic metastasis and Slug expression

From: Evaluation of Slug expression is useful for predicting lymph node metastasis and survival in patients with gastric cancer

Measures

Total patients (N = 459)

Low (n = 104)

Mid (n = 130)

High (n = 225)

P

Lymph node metastasis (pN)

 Negative

164 (35.7%)

66 (63.5%)

51 (39.2%)

47 (20.9%)

<0.001

 Positive

295 (64.3%)

38 (36.5%)

79 (60.8%)

178 (79.1%)

 

  N1

98 (21.4%)

20 (19.2%)

30 (23.1%)

48 (21.3%)

 

  N2

99 (21.6%)

15 (14.4%)

26 (20.0%)

58 (25.8%)

 

  N3

98 (21.4%)

3 (2.9%)

23 (17.7%)

72 (32.0%)

 

   N3a

94 (20.5%)

3 (2.9%)

20 (15.4%)

71 (31.6%)

 

   N3b

4 (0.9%)

0 (0.0%)

3 (2.3%)

1 (0.4%)

 

Number of metastatic lymph nodes

3.7 ± 4.9 (0–42)

1.2 ± 2.3 (0–12)

3.6 ± 5.8 (0–42)

4.9 ± 4.7 (0–25)

<0.001

Number of retrieved lymph nodes

42.4 ± 15.4 (6–106)

39.5 ± 13.3 (14–78)

44.9 ± 16.1* (8–97)

42.4 ± 15.8 (6–106)

0.028

Positive lymph node ratio

0.09 ± 0.12

0.03 ± 0.06

0.08 ± 0.12

0.12 ± 0.13

<0.001

Lymphatic invasiona

 Negative

154 (33.6%)

59 (57.3%)

45 (34.9%)

50 (22.2%)

<0.001

 Positive

303 (66.0%)

44 (42.7%)

84 (65.1%)

175 (77.8%)

 
  1. * p < 0.05; when compared with “low Slug composite score group” using the ANOVA test with post-hoc Tukey-HSD test
  2. aLymphatic invasion could not be evaluated in 2 cases