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Table 3 uPA/PAI-1 and Ki67 levels stratified according to tumour grade

From: Assessment of Ki67 and uPA/PAI-1 expression in intermediate-risk early stage breast cancers

GRADE I
  Positive Negative   Positive vs. negative
uPA/PAI-1
Ki67 uPA+/PAI-1+ uPA +/PAI-1- uPA−/PAI-1+ uPA−/PAI-1- Total P value
< 20% 11 (16) 4 (6) 22 (31) 34 (47) 71 0.5
≥ 20% 1 (33) 0 (0) 0 (0) 2 (67) 3
GRADE II
  Positive Negative   Positive vs. negative
uPA/PAI-1
Ki67 uPA+/PAI-1+ uPA+/PAI-1- uPA−/PAI-1+ uPA−/PAI-1- Total P value
< 20% 42 (25) 15 (9) 43 (25) 70 (41) 170 0.04
≥ 20% 24 (42) 6 (10) 12 (21) 15 (27) 57
GRADE III
  Positive Negative   Positive vs. negative
uPA/PAI-1
Ki67 uPA+/PAI-1+ uPA+/PAI-1- uPA−/PAI-1+ uPA−/PAI-1- Total P value
< 20% 3 (33) 4 (45) 1 (11) 1 (11) 9 0.1
≥ 20% 11 (30) 6 (16) 7 (19) 13 (35) 37
  1. uPA+: uPA ≥3 ng/ml; uPA- < 3 ng/ml; PAI-1+: ≥ 14 ng/ml; PAI-1-: <14 ng/ml. Data are reported as n (%) unless otherwise stated
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