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Table 2 Clinical cut-off values, sensitivity, and specificity of miRNAs

From: MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer

  Cut-off value Sensitivity, % (95% CI) Specificity, % (95% CI) PPV, % (95% CI) NPV, % (95% CI) Likelihood ratio
miR-9 >4.035 67.3 (52.9–79.7) 80.0 (66.3–90.0) 77.8 (62.9–88.8) 70.2 (56.6–81.6) 3.4
miR-21 >1.975 82.7 (69.7–91.8) 72.0 (57.5–83.8) 75.4 (62.2–85.9) 80.0 (65.4–90.4) 3.0
miR-155 >3.880 65.4 (50.9–78.0) 96.0 (86.3–99.5) 94.3 (80.8–90.6) 71.6 (59.3–82.0) 15.9
  1. 95% CI 95% confidence interval, PPV positive predictive value, NPV negative predictive value