Table 2 Clinical cut-off values, sensitivity, and specificity of miRNAs
From: MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer
Cut-off value | Sensitivity, % (95% CI) | Specificity, % (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) | Likelihood ratio | |
|---|---|---|---|---|---|---|
miR-9 | >4.035 | 67.3 (52.9–79.7) | 80.0 (66.3–90.0) | 77.8 (62.9–88.8) | 70.2 (56.6–81.6) | 3.4 |
miR-21 | >1.975 | 82.7 (69.7–91.8) | 72.0 (57.5–83.8) | 75.4 (62.2–85.9) | 80.0 (65.4–90.4) | 3.0 |
miR-155 | >3.880 | 65.4 (50.9–78.0) | 96.0 (86.3–99.5) | 94.3 (80.8–90.6) | 71.6 (59.3–82.0) | 15.9 |