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Table 5 Hazard ratios (HR) and 95% confidence intervals (CI) for breast cancer characteristics in relation to risk of cancer-specific mortality and overall mortality

From: Descriptive characteristics of prostate cancer in patients with a history of primary male breast cancer – a SEER analysis

  Breast cancer-specific mortality Overall mortality
  Crude modela Multivariable-adjusted modelb Crude modela Multivariable-adjusted modelb
  HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI)
Age at index breast cancer, years
 <55 0.77 (0.64–0.92) 0.70 (0.53–0.91) 0.25 (0.22–0.28) 0.20 (0.17–0.24)
 55–64 0.75 (0.63–0.90) 0.63 (0.48–0.82) 0.31 (0.28–0.35) 0.25 (0.22–0.30)
 65–74 0.68 (0.57–0.81) 0.71 (0.55–0.92) 0.44 (0.39–0.48) 0.44 (0.39–0.51)
 75+   Reference   Reference   Reference   Reference
 P trend   <0.001   0.014   <0.001   <0.001
Race/ethnicity
 Non-Hispanic White   Reference   Reference   Reference   Reference
 Black 1.82 (1.54–2.15) 1.70 (1.31–2.20) 1.34 (0.19–1.52) 1.56 (1.31–1.87)
 Asian/Pacific Islander/Alaska Native 0.99 (0.71–1.37) 0.97 (0.60–1.59) 0.77 (0.62–0.97) 0.73 (0.53–0.99)
 Hispanic 1.10 (0.83–1.48) 1.27 (0.85–1.91) 0.93 (0.76–1.13) 1.12 (0.86–1.47)
Breast cancer AJCC stage
 I   Reference   Reference   Reference   Reference
 II 2.53 (2.01–3.17) 1.44 (1.01–2.03) 1.47 (1.31–1.65) 1.31 (1.09–1.56)
 III 6.75 (5.36–8.49) 3.18 (2.12–4.77) 2.48 (2.18–2.82) 2.34 (1.86–2.96)
Hormone receptor status
 ER/PR negative   Reference   Reference   Reference   Reference
 ER and/or PR positive 0.51 (0.39–0.67) 0.71 (0.48–1.05) 0.78 (0.63–0.96) 0.86 (0.65–1.13)
Tumor size         
 <2 cm   Reference   Reference   Reference   Reference
 ≥2 cm 2.90 (2.40–3.50) 1.67 (1.27–2.19) 1.85 (1.66–2.06) 1.22 (1.04–1.44)
Lymph node status
 Negative   Reference   Reference   Reference   Reference
 Positive 3.49 (3.04–4.02) 1.91 (1.46–2.51) 1.54 (1.42–1.68) 1.12 (0.96–1.31)
Radiation
 No   Reference   Reference   Reference   Reference
 Yes 1.59 (1.38–1.81) 0.83 (0.68–1.02) 1.10 (1.00–1.21) 0.77 (0.68–0.89)
  1. aCrude model estimates adjusted for SEER registry and year of diagnosis only
  2. bMultivariable-adjusted model estimates adjusted for age, race/ethnicity, breast cancer AJCC stage, hormone receptor status, tumor size, lymph node status, radiation, surgery, SEER registry and year of diagnosis