Breast cancer-specific mortality | Overall mortality | |||||||
---|---|---|---|---|---|---|---|---|
Crude modela | Multivariable-adjusted modelb | Crude modela | Multivariable-adjusted modelb | |||||
HR | (95% CI) | HR | (95% CI) | HR | (95% CI) | HR | (95% CI) | |
Age at index breast cancer, years | ||||||||
<55 | 0.77 | (0.64–0.92) | 0.70 | (0.53–0.91) | 0.25 | (0.22–0.28) | 0.20 | (0.17–0.24) |
55–64 | 0.75 | (0.63–0.90) | 0.63 | (0.48–0.82) | 0.31 | (0.28–0.35) | 0.25 | (0.22–0.30) |
65–74 | 0.68 | (0.57–0.81) | 0.71 | (0.55–0.92) | 0.44 | (0.39–0.48) | 0.44 | (0.39–0.51) |
75+ | Reference | Reference | Reference | Reference | ||||
P trend | <0.001 | 0.014 | <0.001 | <0.001 | ||||
Race/ethnicity | ||||||||
Non-Hispanic White | Reference | Reference | Reference | Reference | ||||
Black | 1.82 | (1.54–2.15) | 1.70 | (1.31–2.20) | 1.34 | (0.19–1.52) | 1.56 | (1.31–1.87) |
Asian/Pacific Islander/Alaska Native | 0.99 | (0.71–1.37) | 0.97 | (0.60–1.59) | 0.77 | (0.62–0.97) | 0.73 | (0.53–0.99) |
Hispanic | 1.10 | (0.83–1.48) | 1.27 | (0.85–1.91) | 0.93 | (0.76–1.13) | 1.12 | (0.86–1.47) |
Breast cancer AJCC stage | ||||||||
I | Reference | Reference | Reference | Reference | ||||
II | 2.53 | (2.01–3.17) | 1.44 | (1.01–2.03) | 1.47 | (1.31–1.65) | 1.31 | (1.09–1.56) |
III | 6.75 | (5.36–8.49) | 3.18 | (2.12–4.77) | 2.48 | (2.18–2.82) | 2.34 | (1.86–2.96) |
Hormone receptor status | ||||||||
ER/PR negative | Reference | Reference | Reference | Reference | ||||
ER and/or PR positive | 0.51 | (0.39–0.67) | 0.71 | (0.48–1.05) | 0.78 | (0.63–0.96) | 0.86 | (0.65–1.13) |
Tumor size | ||||||||
<2 cm | Reference | Reference | Reference | Reference | ||||
≥2 cm | 2.90 | (2.40–3.50) | 1.67 | (1.27–2.19) | 1.85 | (1.66–2.06) | 1.22 | (1.04–1.44) |
Lymph node status | ||||||||
Negative | Reference | Reference | Reference | Reference | ||||
Positive | 3.49 | (3.04–4.02) | 1.91 | (1.46–2.51) | 1.54 | (1.42–1.68) | 1.12 | (0.96–1.31) |
Radiation | ||||||||
No | Reference | Reference | Reference | Reference | ||||
Yes | 1.59 | (1.38–1.81) | 0.83 | (0.68–1.02) | 1.10 | (1.00–1.21) | 0.77 | (0.68–0.89) |