Table 2 Summary of the median inhibitory concentrations (IC50) of Olaparib and BMN-673 inhibitors on the endometrial cancer cell lines by clonogenic assay
From: Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors
Cell line | Inhibitor | IC50(μM) | Inhibitor | IC50 (μM) |
|---|---|---|---|---|
AN3CA | Olaparib | 0.5 | BMN673 | 0.001 |
Ishikawa | Olaparib | 3 | BMN673 | 0.003 |
HEC-50 | Olaparib | 6 | BMN673 | 0.005 |
HEC-50 shPTEN | Olaparib | 0.1 | BMN673 | 0.004 |
HEC-1B | Olaparib | 10 | BMN673 | 0.125 |
HEC-1B shPTEN | Olaparib | 2.1 | BMN673 | 0.051 |