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Fig. 1 | BMC Cancer

Fig. 1

From: Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors

Fig. 1

PTEN expression and PI3K-AKT-mTOR pathway activation in endometrial cancer cells. a In 12% SDS gel western blot using protein extracts collected in standard conditions (Media containing 10% FBS), HEC-50 and HEC-1B cells expressed PTEN protein, while AN3CA and Ishikawa did not. As expected with such a mutation, Ishikawa had high level of phospho-AKT (p-AKT) and phospho-S6 (p-S6). HEC-50, displayed a lower level of p-AKT despite a PTEN mutation. b Reduced expression of PTEN was observed in HEC-50 and HEC-1B transfected with shPTEN. Results shown are one representative experiment out of three independent experiments

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