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Fig. 2 | BMC Cancer

Fig. 2

From: Circadian disruption promotes tumor growth by anabolic host metabolism; experimental evidence in a rat model

Fig. 2

Constant light (LL) disrupts metabolism. (a) LL rats (white circles) gained more body weight along the 5-week protocol as compared with LD rats (grey circles). The repeated-measures two-way ANOVA indicated significant interaction of the lighting condition versus time, p = 0.0011. The Bonferroni test **p < 0.01 indicated statistical difference from LD. (b) Food ingestion assessed for 24 h during week 5 indicated no differences between groups. Data are expressed as mean ± SEM (n = 7–8/group). (c) Basal plasma TG and (d) glucose levels under ad libitum and fasted conditions were significantly increased in LL rats. Data are the mean ± SEM (n = 12/group), **p < 0.01 indicates statistical difference from LD; unpaired t test. (e) Glucose tolerance test (GTT, 0–120 min) and (f) area under the curve (AUC) following i.p. administration of 1 g of glucose/kg. Data are the means ± SEM (n = 1415/group). * p < 0.05 indicates statistical difference from LD; unpaired t test

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