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Table 2 Cancer pathway genes significantly upregulated after Rep stress (but not after Acu)

From: Stress alters the expression of cancer-related genes in the prostate

Gene ID/ Accession Gene name Fold change
Con vs Rep
Molecular function/biological process
Acly P16638 ATP citrate lyase 2.14 Lyase enzyme/metabolism (bioenergetics)
Angpt1 O35460 Angiopoietin 1 1.91 Vascular growth factor/angiogenesis
Apaf1 Q9EPV5 Apoptotic peptidase activating factor 1 1.42 Endopeptidase/apoptosis
Atp5a1 P15999 ATP synthase, H+ transpoting, mitochondrial F1 complex, alpha subunit 1.84 ATP synthesis/metabolism (bioenergetics)
Casp2 P55215 Caspase 2 2.10 Endopeptidase/apoptosis
Casp7 O88550 Caspase 7 1.87 Endopeptidase/apoptosis
Casp9 Q920G4 Caspase 9, apoptosis-related cysteine peptidase 1.96 Endopeptidase/apoptosis
Ccnd3 P48961 Cyclin D3 1.54 Kinase/cell cycle regulation
Cdc20 Q62623 Cell division cycle 20 homolog (S. cerevisiae) 1.92 Regulatory protein/cell cycle regulation
Cdh2 Q9Z1Y3 Cadherin 2 3.07 Cell adhesion
Cflar C0H5Y5 CASP8 and FADD-like apoptosis regulator 2.08 Endopeptidase/apoptosis
Cpt2 P18886 Carnitine palmitoyltransferase 2 2.06 Lipid transferase/metabolism (fatty acid)
Dkc1 P40615 Dyskeratosis congenita 1, dyskerin 1.66 rRNA processing/proliferation
E2f4 D4A9V4 E2F transcription factor 4 2.10 Transcription factor/proliferation
Ercc5 D3ZTV2 Excision repair cross-complementing rodent repair deficiency, Complementation group 5 1.85 Endonuclease/DNA excision repair
Flt1 P53767 Fms-related tyrosine kinase 1 2.77 Growth factor receptor/proliferation, migration
Foxc2 Q63246 Forkhead box C2 1.91 Transcription factor/proliferation, differentiation
G6pd P05370 Glucose −6-phosphate dehydrogenase 2.38 Dehydrogenease/metabolism (carbohydrates)
Igfbp7 Q5RJM3 Insulin-like growth factor binding protein 7 1.89 Growth factor binding/response to hormones
Map2k1 Q01986 Mitogen activated protein kinase kinase 1 1.83 Mitogenic protein kinase/proliferation
Nol3 Q62881 Nucleolar protein 3 (apoptosis repressor with CARD domain) 2.11 Regulatory protein/apoptosis
Pgf Q63434 Placental growth factor 1.60 Growth factor/proliferation, differentiation
Pp1r15a Q6IN02
Protein phosphatase 1, regulatory (inhibitor) subunit 15A 1.91 Phosphatase/apoptosis
Sod1 P07632 Superoxide dismutase 1, soluble 1.96 Dismutase enzyme/oxidative stress
Wee1 Q63802 Wee 1 homolog (S. pombe) 1.29 Kinase/cell cycle regulation
  1. Bold text denotes proto-oncogenes. Accession numbers and molecular function/biological process obtained from UniProtKB database