Table 3 Assessment for heterogeneity using a percent positive binarization cut-point of >10
Variable | Levels | PD-L1%Positive < 10 | PD-L1%Positive > 10 | P-Value |
|---|---|---|---|---|
Age | Median [IQR] | 66.5 [13.1] | 65.6 [20.5] | 0.96 |
Sex | Male | 132 (55.0%) | 7 (58.3%) | 1.0 |
Female | 108 (45.0%) | 4 (41.8%) | ||
Adjuvant Chemotherapy | Given | 71 (29.6%) | 3 (25.0%) | 1.0 |
Observation | 169 (70.4%) | 9 (75.0%) | ||
Histologic Grade | 1 | 2 (0.8%) | 0 (0.0%) | 0.029 |
2 | 181 (75.4%) | 5 (41.7%) | ||
3 | 57 (23.8%) | 7 (58.3%) | ||
Lymphovascular Invasion | Present | 136 (56.7%) | 8 (66.7%) | 0.56 |
Absent | 104 (43.3%) | 4 (33.3%) | ||
Perineurial Invasion | Present | 221 (92.1%) | 11 (91.7%) | 1.0 |
Absent | 19 (7.9%) | 1 (9.3%) | ||
pT Stage | 1 | 2 (0.8%) | 0 (0.0%) | 0.88 |
2 | 10 (4.2%) | 1 (8.3%) | ||
3 | 227 (94.6%) | 11 (91.7%) | ||
4 | 1 (0.4%) | 0 (0.0%) | ||
pN Stage | 0 | 62 (25.8%) | 2 (16.7%) | 0.74 |
1 | 178 (74.2%) | 10 (83.3%) | ||
Resection Status | R0 | 184 (76.7%) | 6 (50%) | 0.08 |
R1 | 56 (23.3%) | 6 (50%) | ||
CD3 Epithelial | Median [IQR] | 0 [0] | 0 [4] | 0.16 |
CD3 Stromal | Median [IQR] | 50 [52] | 63 [76] | 0.52 |
CD8 Epithelial | Median [IQR] | 0 [0] | 0 [0] | 0.51 |
CD8 Stromal | Median [IQR] | 11 [36] | 14 [39] | 0.72 |
MMR Status | Proficient | 200 (83.7%) | 11 (91.7%) | 0.70 |
Deficient | 39 (16.3%) | 1 (8.3%) |