Table 2 Associations between the clinical and laboratory characteristics of the patients and SMAD in univariate and multivariate logistic regression analysis

Age (≥ 45 vs. < 45 years)

0.850–1.535

Gender (Male vs. Female)

0.410–0.946

Smoking Status (Present vs. Absent)

0.993–1.807

Drinking Status (Present vs. Absent)

0.655–1.647

Family history (Present vs. Absent)

0.649–1.267

Calcium, mmol/L (≥ 2.4 vs. < 2.4)

0.734–1.327

Phosphorus, mmol/L (≥ 1.15 vs. < 1.15)

0.685–1.239

Magnesium, mmol/L (≥ 0.93 vs. < 0.93)

0.636–1.154

CRP, mg/L (≥ 1.91 vs. < 1.91)

1.583–2.965

WBCs, ×10⁹ (≥ 6.9 vs. < 6.9)

0.931–1.684

Neutrophils, ×10⁹ (≥ 4.2 vs. < 4.2)

1.241–2.276

HGB, g/L (≥ 145 vs. < 145)

0.488–0.893

0.477–0.948

Platelets, ×10⁹ (≥ 229 vs. < 229)

1.083–1.974

ALT, U/L (≥ 22.2 vs. < 22.2)

0.846–1.530

AST, U/L (≥ 21 vs. < 21)

0.958–1.736

ALP, U/L (≥ 70 vs. < 70)

2.024–3.893

1.509–3.056

LDH, U/L (≥ 172.2 vs. < 172.2)

1.789–3.396

1.069–2.139

ALB, g/L (≥ 44.9 vs. < 44.9)

0.466–0.854

GLB, g/L (≥ 30.5 vs. < 30.5)

0.822–1.486

Cholesterol, mmol/L (≥ 5.12 vs. < 5.12)

0.554–1.006

T lymphocytes, ×10⁹ (≥ 1.8 vs. < 1.8)

0.632–1.147

Monocytes, ×10⁹ (≥ 0.4 vs. < 0.4)

1.133–2.062

Pathology (Differentiated vs. Undifferentiated

0.492–2.363

Cranial nerve injury (Absent vs. Present)

0.491–1.646

EBV-DNA, copies/ml

  < 1000

1.000

1.000

 1000–9999

0.952–2.534

0.784–2.131

 10,000–99,999

1.459–3.558

0.998–2.530

 100,000–999,999

3.354–8.307

1.982–5.279

  ≥ 1,000,000

10.822–32.544

5.876–19.498

T category

 1

1.000

 2

0.629–2.818

 3

0.653–2.663

 4

0.692–3.007

N category

 0

1.000

1.000

 1

0.750–3.893

0.559–2.984

 2

2.276–10.933

1.304–6.557

 3

2.232–11.035

0.996–5.306

 4

2.504–15.887

0.983–6.905