Fig. 2

Analysis of GPR155 expression in clinical specimens. a There were no significant differences in GPR155 mRNA levels among non-cancerous tissues categorized by background uninvolved liver status. b GPR155 mRNA was expressed at lower levels in HCC tissues compared with corresponding non-cancerous tissues. c Correlation of GPR155 mRNA expression levels in HCC tissues with preoperative serum α-fetoprotein levels. d Detection of GPR155 protein in two representative patients. In both cases, cancerous tissues exhibited reduced expression compared with adjacent non-cancerous tissues (100× and 400× magnification). N, non-cancerous component; T, tumor component. A significant correlation between staining intensity and transcription patterns of GPR155 was observed