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Table 1 Correlation of XIAP with clinico-pathological parameters in Breast Cancer

From: XIAP over-expression is an independent poor prognostic marker in Middle Eastern breast cancer and can be targeted to induce efficient apoptosis

  Total XIAP Over-expression XIAP Low-expression P value
  N % N % N %
Total Number of Cases 964   284 29.5 680 70.5  
Age Groups
  < 50 306 31.7 87 28.4 219 71.6 0.6320
  > 50 658 68.3 197 29.9 461 70.1  
Tumor sizea
  ≤ 2 cm 208 22.1 46 22.1 162 77.9 0.0044
  > 2 cm 731 77.9 236 32.1 498 67.9  
Lymph Nodes involvementa
 Negative 300 33.3 81 27.0 219 73.0 0.3914
 Positive 602 66.7 179 29.7 423 70.3  
Metastasisa
 M0 776 89.8 225 29.0 551 71.0 0.1587
 M1 88 10.2 32 36.4 56 63.6  
 Tumor Stagea
 I 76 9.1 19 25.0 57 75.0 0.4453
 II 366 43.7 107 29.2 259 70.8  
 III 307 36.7 91 29.6 216 70.4  
 IV 88 10.5 32 36.4 56 63.6  
Extra Nodal Ext.a
 Present 262 33.2 92 35.1 170 64.9 0.0041
 Absent 527 66.8 133 25.2 394 74.8  
 LVIa
 Present 350 41.0 110 31.4 240 68.6 0.1411
 Absent 504 59.0 135 26.8 369 73.2  
Histological Grade a
 Well differentiated 72 7.6 10 13.9 62 86.1 <0.0001
 Moderately differentiated 489 51.3 123 25.1 366 74.9  
 Poorly differentiated 393 41.2 150 38.2 243 61.8  
Histologya
 Infiltrating Ductal Carcinoma 878 93.7 272 31.0 606 69.0 0.0002
 Infiltrating Lobular 43 4.6 3 7.0 40 93.0  
 Mucinous Ca 16 1.7 2 12.5 14 87.5  
Triple Negativea
 No 815 84.9 225 27.6 590 72.4 0.0019
 Yes 145 15.1 59 40.7 86 59.3  
Ki-67 IHCa
 High 610 64.3 214 35.1 396 64.9 <0.0001
 Low 339 35.7 66 19.5 273 80.5  
PARPa
 High 433 45.2 159 36.7 274 63.3 <0.0001
 Low 525 54.8 125 23.8 400 76.2  
phos_AKT (473)a
 Negative 728 77.4 181 24.9 547 75.1 <0.0001
 Positive 212 22.6 100 47.2 112 52.8  
Survival
 OS 5 Years     71.8   82.8 0.0005
  1. aData was not available (NA) for some cases: Tumor size (NA = 25), Lymph nodes (NA = 62), Metastasis (NA = 100), Tumor Stage (NA = 127), Extra Nodal Ext. (NA = 175), LVI (NA = 110), Histological Grade (NA = 10), Histology (NA = 27), Triple Negative (NA = 04), Ki-67 (NA = 15), PARP (NA = 06), & phos. AKT(473) (NA = 24)