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Table 6 Correlation between Ad-mediated cytotoxicity and the transcriptional activity used in E1 activation

From: Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes

Tumor type Transcriptional Correlation coefficient P value
Ad-mediated cytotoxicitya activityb  
Pancreatic carcinoma
 Ad5/MK MK 0.57 0.43
 Ad5/Sur Sur 0.80 0.20
 Ad5/COX-2 COX-2 −0.58 0.42
 AdF35/MK MK −0.16 0.84
 AdF35/Sur Sur 0.99 0.01c
 AdF35/COX-2 COX-2 −0.18 0.81
Esophageal carcinoma
 Ad5/MK MK 0.17 0.67
 Ad5/Sur Sur −0.18 0.65
 Ad5/COX-2 COX-2 0.60 0.09
 AdF35/MK MK 0.18 0.65
 AdF35/Sur Sur 0.19 0.62
 AdF35/COX-2 COX-2 0.48 0.19
Mesothelioma
 Ad5/MK MK −0.07 0.92
 AdF35/Sur Sur −0.27 0.66
 Ad5/COX-2 COX-2 0.08 0.92
 AdF35/MK MK −0.25 0.68
 Ad5/Sur Sur −0.53 0.36
 AdF35/COX-2 COX-2 0.54 0.35
  1. aCytotoxicity data are expressed as IC50 values of respective cells, 4 pancreatic, 9 esophageal and 5 mesothelioma cell lines as shown in Table 1
  2. bTranscriptional activity data are percentages of the SV40 T antigen promoter-mediated luciferase activity as shown in Table 5
  3. cStatistically significant