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Table 4 Correlation between Ad-mediated cytotoxicity and Ad infectivity/gene expression

From: Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes

Tumor type Infectivityb Correlation coefficient P value
Ad-mediated cytotoxicitya
Pancreatic carcinoma
 Ad5/MK Ad5/GFP 0.77 0.22
 Ad5/Sur Ad5/GFP 0.05 0.95
 Ad5/COX-2 Ad5/GFP 0.94 0.06
 AdF35/MK AdF35/GFP −0.89 0.11
 AdF35/Sur AdF35/GFP 0.31 0.69
 AdF35/COX-2 AdF35/GFP 0.14 0.86
Esophageal carcinoma
 Ad5/MK Ad5/GFP −0.15 0.70
 Ad5/Sur Ad5/GFP −0.52 0.15
 Ad5/COX-2 Ad5/GFP −0.22 0.56
 AdF35/MK AdF35/GFP −0.36 0.34
 AdF35/Sur AdF35/GFP −0.28 0.47
 AdF35/COX-2 AdF35/GFP −0.53 0.13
Mesothelioma
 Ad5/MK Ad5/GFP −0.57 0.31
 Ad5/Sur Ad5/GFP −0.65 0.24
 Ad5/COX-2 Ad5/GFP −0.18 0.82
 AdF35/MK AdF35/GFP 0.10 0.87
 AdF35/Sur AdF35/GFP 0.07 0.91
 AdF35/COX-2 AdF35/GFP 0.15 0.82
  1. aCytotoxicity data are expressed as IC50 values of respective cells, 4 pancreatic, 9 esophageal carcinoma and 5 mesothelioma cells as shown in Table 1
  2. bInfectivity data are percentages of GFP-positive cells infected at Ad5/GFP or AdF35/GFP at 30 MOI as shown in Table 2