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Fig. 1 | BMC Cancer

Fig. 1

From: Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes

Fig. 1

Cytotoxicity of esophageal carcinoma to replication-competent Ad in terms of the p53 genotypes and p21 responses to cisplatin treatments. Ad-mediated cytotoxicity was expressed as IC50 values, which was tested with Ad5/MK, AdF35/MK, Ad5/Sur, AdF35/Sur, Ad5/COX-2 and AdF35/COX-2. A response of p21 levels to cisplatin was judged from Western blot analysis in Fig. 2. Non-decreased cells were YES-2, YES-4 and YES-6, and decreased cells were TE-1, TE-10, TE-11, YES-5 and T.Tn cells

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