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Table 1 Hh protein expression in benign and cancerous prostate tissue

From: Tissue microarray analysis indicates hedgehog signaling as a potential prognostic factor in intermediate-risk prostate cancer

  Benign prostate (n) Prostate cancer (n) Fisher’s exact test (2-sided)
Epithelial expression Low (%) High (%) Low (%) High (%) p-value
SHH 46 (76.6) 14 (23.3) 111 (71.6) 44 (28.4) 0.497
PTCH1 17 (26.6) 47 (73.4) 114 (76) 36 (24) <0.001
SMO 3 (4.7) 61 (95.3) 5 (3.2) 150 (96.8) 0.695
SUFU 19 (30.6) 43 (69.4) 26 (16.9) 128 (83.1) 0.028
GLI1 44 (73.3) 16 (26.7) 130 (83.9) 25 (16.1) 0.061
GLI2 5 (8.2) 56 (91.8) 54 (36.5) 94 (63.5) <0.001
GLI3 18 (29) 44 (71) 85 (55.2) 69 (44.8) 0.001
Cyclin D1 54 (93.1) 4 (6.9) 94 (61.4) 59 (38.6) <0.001
SNAIL 24 (39.3) 37 (60.7) 31 (20) 124 (80) 0.005
SNAI3 59 (95.2) 3 (4.8) 134 (86.5) 21 (13.5) 0.092
Stromal expression      
SHH 65 (100) 0 153 (100) 0 NA
PTCH1 65 (100) 0 152 (100) 0 NA
SMO 62 (95.4) 3 (4.6) 143 (94.7) 8 (5.3) 1.000
SUFU 23 (36.5) 40 (63.5) 25 (18.1) 113 (81.9) 0.007
GLI1 58 (93.5) 4 6.5) 141 (91.6) 13 (8.4) 0.783
GLI2 60 (93.8) 4 (6.3) 136 (95.1) 7 (4.9) 0.741
GLI3 63 (98.4) 1 (1.6) 146 (98) 3 (2) 1.000
  1. Statistical significant results are presented in Italic