| |
Benign prostate (n)
|
Prostate cancer (n)
|
Fisher’s exact test (2-sided)
|
|---|
|
Epithelial expression
|
Low (%)
|
High (%)
|
Low (%)
|
High (%)
|
p-value
|
|---|
|
SHH
|
46 (76.6)
|
14 (23.3)
|
111 (71.6)
|
44 (28.4)
|
0.497
|
|
PTCH1
|
17 (26.6)
|
47 (73.4)
|
114 (76)
|
36 (24)
|
<0.001
|
|
SMO
|
3 (4.7)
|
61 (95.3)
|
5 (3.2)
|
150 (96.8)
|
0.695
|
|
SUFU
|
19 (30.6)
|
43 (69.4)
|
26 (16.9)
|
128 (83.1)
|
0.028
|
|
GLI1
|
44 (73.3)
|
16 (26.7)
|
130 (83.9)
|
25 (16.1)
|
0.061
|
|
GLI2
|
5 (8.2)
|
56 (91.8)
|
54 (36.5)
|
94 (63.5)
|
<0.001
|
|
GLI3
|
18 (29)
|
44 (71)
|
85 (55.2)
|
69 (44.8)
|
0.001
|
|
Cyclin D1
|
54 (93.1)
|
4 (6.9)
|
94 (61.4)
|
59 (38.6)
|
<0.001
|
|
SNAIL
|
24 (39.3)
|
37 (60.7)
|
31 (20)
|
124 (80)
|
0.005
|
|
SNAI3
|
59 (95.2)
|
3 (4.8)
|
134 (86.5)
|
21 (13.5)
|
0.092
|
|
Stromal expression
| | | | | |
|
SHH
|
65 (100)
|
0
|
153 (100)
|
0
|
NA
|
|
PTCH1
|
65 (100)
|
0
|
152 (100)
|
0
|
NA
|
|
SMO
|
62 (95.4)
|
3 (4.6)
|
143 (94.7)
|
8 (5.3)
|
1.000
|
|
SUFU
|
23 (36.5)
|
40 (63.5)
|
25 (18.1)
|
113 (81.9)
|
0.007
|
|
GLI1
|
58 (93.5)
|
4 6.5)
|
141 (91.6)
|
13 (8.4)
|
0.783
|
|
GLI2
|
60 (93.8)
|
4 (6.3)
|
136 (95.1)
|
7 (4.9)
|
0.741
|
|
GLI3
|
63 (98.4)
|
1 (1.6)
|
146 (98)
|
3 (2)
|
1.000
|
- Statistical significant results are presented in Italic
