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Table 1 Hh protein expression in benign and cancerous prostate tissue

From: Tissue microarray analysis indicates hedgehog signaling as a potential prognostic factor in intermediate-risk prostate cancer

 

Benign prostate (n)

Prostate cancer (n)

Fisher’s exact test (2-sided)

Epithelial expression

Low (%)

High (%)

Low (%)

High (%)

p-value

SHH

46 (76.6)

14 (23.3)

111 (71.6)

44 (28.4)

0.497

PTCH1

17 (26.6)

47 (73.4)

114 (76)

36 (24)

<0.001

SMO

3 (4.7)

61 (95.3)

5 (3.2)

150 (96.8)

0.695

SUFU

19 (30.6)

43 (69.4)

26 (16.9)

128 (83.1)

0.028

GLI1

44 (73.3)

16 (26.7)

130 (83.9)

25 (16.1)

0.061

GLI2

5 (8.2)

56 (91.8)

54 (36.5)

94 (63.5)

<0.001

GLI3

18 (29)

44 (71)

85 (55.2)

69 (44.8)

0.001

Cyclin D1

54 (93.1)

4 (6.9)

94 (61.4)

59 (38.6)

<0.001

SNAIL

24 (39.3)

37 (60.7)

31 (20)

124 (80)

0.005

SNAI3

59 (95.2)

3 (4.8)

134 (86.5)

21 (13.5)

0.092

Stromal expression

     

SHH

65 (100)

0

153 (100)

0

NA

PTCH1

65 (100)

0

152 (100)

0

NA

SMO

62 (95.4)

3 (4.6)

143 (94.7)

8 (5.3)

1.000

SUFU

23 (36.5)

40 (63.5)

25 (18.1)

113 (81.9)

0.007

GLI1

58 (93.5)

4 6.5)

141 (91.6)

13 (8.4)

0.783

GLI2

60 (93.8)

4 (6.3)

136 (95.1)

7 (4.9)

0.741

GLI3

63 (98.4)

1 (1.6)

146 (98)

3 (2)

1.000

  1. Statistical significant results are presented in Italic