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Fig. 3 | BMC Cancer

Fig. 3

From: IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer

Fig. 3

Activation of IGF pathway in bladder tumor is correlated with expression of some components of this pathway. a RPPA signal for phosphorylated IGF1R/INSR by tumor stages; b Spearman’s coefficient for the correlations between mRNA levels for IGF receptors, ligands, and binding proteins and the phosphorylated IGF1R/INSR RPPA signal; c heat map for the expression of IGF receptor, ligand, and binding protein genes in tumors, in decreasing order of phosphorylated IGF1R/INSR RPPA signal in the FBLAD-Exon dataset. Color intensity (blue-red scale) is centered on the mean value for expression in normal bladder samples

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