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Table 3 Multivariate analysis of prognostic factors based on Cox proportional hazards regression model in 136 primary PCa patients progressing to metastatic hormone-sensitive disease after curative treatment

From: The outcome of prostate cancer patients treated with curative intent strongly depends on survival after metastatic progression

Variable

Hazard ratio

95% CI

p-value

Age at diagnosis (years)

1.05

0.97–1.13

0.213

PSA (ng/ml)

 10–20 vs < 10

0.31

0.09–1.13

0.076

  > 20 vs < 10

1.47

0.66–3.29

0.348

Stage

 T3-T4 vs T1-T2

0.82

0.31–2.38

0.687

Gleason Score

  > 7 vs ≤ 7

2.47

1.15–5.29

0.020*

Site of metastasis at first progression

 Bone-only vs Loco/LN-only

3.88

1.37–10.98

0.011*

 Visceral-only vs Loco/LN-only

1.89

0.20–18.10

0.582

 Multiple site vs Loco/LN-only

3.56

1.24–10.24

0.019*

  1. CI Confidence interval; * significant value