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Table 2 Expression level of TGFβ pathway related proteins in TRAP-overexpressing MDA-MB-231 cells

From: Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes metastasis-related properties via TGFβ2/TβR and CD44 in MDA-MB-231 breast cancer cells

   TRAP3high vs control
Gene name Description Protein log2(ratio H/L) – Replicates average Fold change (H/L) – Replicates average Significancea
TβR1 TGF-beta receptor type-1 1.15 2.22 Significantly reg.
TβR2 TGF-beta receptor type-2 0.97 1.95 ns
TβR3 TGF-beta receptor type-3 0.69 1.62 ns
TGFβ1 Transforming growth factor beta-1 −0.27 0.83 ns
TGFβ2 Transforming growth factor beta-2 2.25 4.77 Significantly reg.
TGFβ1I1 Isoform 2 of Transforming growth factor beta-1-induced transcript 1 protein −0.42 0.75 ns
TGFβ I Transforming growth factor-beta-induced protein ig-h3 0.45 1.36 ns
TGIF1 TGFB-induced factor homeobox 1 0.80 1.75 ns
TGIF2 TGFB-induced factor homeobox 2 −0.76 0.59 ns
SMAD1 Mothers against decapentaplegic homolog 1 0.19 1.14 ns
SMAD2 Mothers against decapentaplegic homolog 2 1.34 2.52 Significantly reg.
SMAD3 Mothers against decapentaplegic homolog 3 0.19 1.14 ns
SMAD4 Mothers against decapentaplegic homolog 4 0.78 1.72 ns
SMAD5 Mothers against decapentaplegic homolog 5 −0.19 0.87 ns
  1. aSignificance describes whether the level of the indicated protein is significantly altered in TRAP3high compared to control cells, based on cutoffs for log2(ratio) of −/+ 2.5 MAD away from the median (see Material and methods). “ns” indicates that the measured protein level is not significantly changed in TRAP3high cells
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BMC Cancer

ISSN: 1471-2407

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