The association between smoking and breast cancer characteristics and outcome

BMC Cancer

Table 3 Histological and molecular characteristics

Population (num)	Histology^a				Grade		ER		PR		Ki67 (%)		P53 (%)		Angiolymphatic invasion		PNI
Population (num)	IDC (%)	ILC (%)	Other (%)	P	Mean (SD)	P	Mean (SD)	P	Mean (SD)	P	Mean (SD)	P	Mean (SD)	P	yes (%)	P	yes (%)	P
All (662)	80.8	12.4	6.8	-	2.02 (0.59)	-	2.47 (0.57)	-	1.47 (1.19)	-	16 (14)	-	7.0 (17.0)	-	6.0	-	4.4	-
Hx smoking^b					2		2.47		1.51		16.0		6.0
smoking^b	80.3	13.9	5.8		(0.59)		(0.57)		(1.49)		(13.0)		(17.0)		7.3		5.5
Yes (173)	80.0	12.5	7.5	0.701	2.04	0.535	2.47	0.97	1.48	0.805	16.0	0.854	7.0	0.582	5.4	0.388	3.8	0.358
No (439)					(0.6)		(0.58)		(1.07)		(14.0)		(17.0)
Current					2.02		2.39		1.4		17.0		7.0
smoking^b	81.2	15.8	3.0		(0.58)		(0.59)		(1.08)		(15.0)		(18.0)		10.4		8.3
Yes (101)	79.7	12.4	7.9	0.16	2.02	0.975	2.49	0.118	1.51		16.0	0.696	7.0	0.879	5.1	0.045	3.5	0.031
No (508)					(0.6)		(0.58)		(1.22)	0.41	(14.0)		(17.0)
Number of pack years (PY)
PY² 0–29					2.03		2.47		1.52		16.0		7.0
(518)	79.6	12.7	7.7		(0.6)		(0.58)		(1.22)		(14.0)		(17.0)		6.0		4.0
PY > =30	84.9	12.1	3.0	0.365	2.0	0.712	2.4		1.27		14.0		5.0	0.523	7.7	0.609	7.7	0.18
(66)					(0.53)		(0.62)	0.377	(1.03)	0.112	(12.0)	0.225	(16.0)

^aOther subtype histology includes: medullary, mucinous, papillary and tubular carcinoma
^bData regarding smoking was retrieved during the first visit at the oncologist clinic. Current smokers were defined as patients who actively smoked at the time of breast cancer diagnosis. Patients with history of smoking were defined as ever smoker
- Abbreviations: ER estrogen receptor, Hx history, PNI perineural invasion, PR progesterone receptor, PY pack years
- Data were not available for: Angiolymphatic invasion (n = 25); Grade (n = 116); Hx smoking (n = 49); Ki67 (n = 179); P53 (n = 287); PNI (n = 25); PY (n = 77); smoking status (n = 52)
- Cohort included patients with ER positive, HER2 negative disease

ISSN: 1471-2407