The association between smoking and breast cancer characteristics and outcome

BMC Cancer

Table 2 Tumor burden and Oncotype DX recurrence score

Population (num)	Tumor size		Macroscopic node positive^a		Stage (%)				Oncotype Dx RS
Population (num)	Mean cm (SD)	P	(%)	P	I	II	III	P	Mean (SD)	P
All (662)	1.67 (0.78)	_	8.8	_	71.3	28.4	0.3	_	19.03 (10.23)	_
Hx smoking^b
Yes (173)	1.66 (0.87)	0.642	9.9	0.574	73.8	25.6	0.6	0.695	18.69 (9.15)	0.447
No (439)	1.69 (0.75)	0.642	8.5	0.574	69.4	30.4	0.2	0.695	19.35 (10.78)	0.447
Current smoking^b
Yes (101)	1.76 (0.98)	0.392	8	0.73	73.0	26.0	1.0	0.613	19.42 (8.52)	0.70
No (508)	1.67 (0.74)	0.392	9.1	0.73	70.2	29.6	0.2	0.613	19.05 (10.49)	0.70
Number of pack years (PY)
PY² 0–29 (518)	1.68 (0.76)	0.82	9.5	0.38	69	30.6	0.4	0.172	19.25 (10.66)	0.454
PY > =30 (66)	1.65 (0.96)	0.82	6.2	0.38	80.0	20.0	0	0.172	18.37 (8.68)	0.454

^aMacroscopic nodes- lymph node metastases >2 mm
^bData regarding smoking was retrieved during the first visit at the oncologist clinic. Current smokers were defined as patients who actively smoked at the time of breast cancer diagnosis. Patients with history of smoking were defined as ever smoker
- Abbreviations: cm centimeter, Hx history, PY pack years, RS recurrence score, SD standard deviation
- Data were not available for: Hx smoking (n = 49); nodal status (n = 2); PY (n = 77); smoking status (n = 52); Stage (n = 2); Tumor size (n = 1)
- Cohort included patients with ER positive, HER2 negative disease

ISSN: 1471-2407