Schematic model structure. (Abbreviations: ADE-adverse drug event, LY-life years gained, QALY-quality adjusted-life years, AO-Adjuvant!Online, ODX-OncotypeDX), L-Low, Int./I-intermediate, H-High, combinations of risk classification (first letter representing Adjuvant!Online, second letter representing OncotypeDX: L-L, L-I, L-H, L-N, I-L, I-I, I-H, I-N, H-L, H-I, H-H, H-N). Source: adapted from Jahn et al. Lessons learned from a cross-model validation between a discrete event simulation model and a cohort state-transition model for personalized breast cancer treatment. Med Decis Making. 2016;36(3):375–390. Copyright © 2016 by Society for Medical Decision Making. Reprinted by permission of SAGE Publications, Inc.