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Table 1 Correlation of nucleus and cytoplasmic ERα and ERβ1 with clinicopathological parameters in ovarian cancer

From: Differential expression of estrogen receptor subtypes and variants in ovarian cancer: effects on cell invasion, proliferation and prognosis

Characteristics Case (n) Nucleus ERα Cytoplasmic ERα   Nucleus ERβ1   Cytoplasmic ERβ1  
   Mean ± SD p-value Mean ± SD p-value   Mean ± SD p-value   Mean ± SD p-value  
Stage (FIGO)
 Early (I-II) 49 3.71 ± 3.32    1.00 ± 1.75    5.60 ± 1.94    3.65 ± 1.67   
 Late (III-IV) 37 5.54 ± 3.12 0.012 * 0.22 ± 0.92 0.016 * 6.35 ± 1.64 0.052*   2.84 ± 1.39 0.101*  
Histological grade
 Low (1–2) 56 4.11 ± 3.48    0.80 ± 1.62    6.25 ± 1.97    3.39 ± 1.67   
 High (3) 33 4.85 ± 3.08 0.370*   0.36 ± 1.17 0.178*   5.42 ± 1.68 0.046 * 2.79 ± 1.43 0.046 *
Histology
 Serous 35 5.43 ± 3.15    0.34 ± 1.14    6.40 ± 1.94    2.91 ± 1.46   
 Clear Cell 17 1.06 ± 2.02    0.71 ± 1.58    6.76 ± 1.64    3.06 ± 1.78   
 Mucinous 9 2.22 ± 2.73    0.44 ± 1.33    5.56 ± 2.46    3.44 ± 2.40   
 Endometrioid 29 5.90 ± 2.68 < 0.001   1.10 ± 1.82 0.230   5.20 ± 1.54 0.021   3.40 ± 1.35 0.567  
 Serous/Clear Cell 52 4.00 ± 3.49    0.46 ± 1.29    6.52 ± 1.84    2.96 ± 1.56   
 Mucinous/Endometrioid 38 5.05 ± 3.09 0.143*   0.95 ± 1.72 0.129*   5.28 ± 1.76 0.003 * 3.41 ± 1.62 0.157*  
 Clear Cell 17 1.06 ± 2.02    0.71 ± 1.58    6.76 ± 1.64    3.06 ± 1.78   
 Non-Clear Cell 73 5.23 ± 3.10 < 0.001 * 0.66 ± 1.49 0.905*   5.81 ± 1.92 0.053*   3.18 ± 1.56 0.593*  
Chemosensitivitya
 Sensitive 63 4.64 ± 3.12    0.76 ± 1.58    6.12 ± 1.93    3.14 ± 1.70   
 Resistant 13 4.38 ± 3.97 0.885*   0.31 ± 1.11 0.325*   5.85 ± 1.46 0.609*   2.77 ± 0.73 0.409*  
  1. Those with significant P-values are underlined. ↑Increase expression. ↓Decrease expression
  2. *Mann–Whitney test; Kruskal–Wallis rank test
  3. aChemosensitive-patients remained disease free more than 6 months after completion of first-line chemotherapy
  4. Intensity values are expressed as “Histoscores” as specified in Methods