Table 8 Summary of published data from tumor MMR analysis from suspected Latin America LS families
Latin America published data | Number of families | Number of individuals | Clinical criteria | MMR deficient (%) | MMR non-deficient (%) | Loss IHC | Â | MSI | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AMSII | Revised Bethesda | Other criteria | MLH1 (%) | PMS2 (%) | MSH2 (%) | MSH6 (%) | PMS1 or MSH3* (%) | MSI-H (%) | MSS (%) | |||||
Medellin, Colombia [16] | 41 | 41 | 4 | 27 | 10 | 14 (34.1) | 27 (65.9) | na | na | na | na | na | 14 (34.1) | 27 (65.9) |
Rosario Santa Fe, Argentina [14] | 1 | 3 | 1 | na | na | 1 (33.3) | 2 (66.7) | na | na | na | na | na | 1 (33.3) | 2 (66.7) |
Sao Paulo, Brazil [15] | 106 | 106 | na | na | na | 14 (13.2) | 92 (86.8) | na | na | na | na | na | 14 (13.2) | 91 (85.9) |
Buenos Aires, Argentina [18] | 41 | 40 | 16 | 0 | 25 | 18 (45) | 22 (55) | 12 (30) | na | 7 (17.5) | na | na | 13 (32.5) | 17 (42.5) |
Minas Gerais, Brazil [22] | 66 | 66 | 8 | 15 | 43 | 15 (22.7) | 51 (77.3) | na | na | na | na | na | 15 (22.7) | 51 (77.3) |
San Juan, Puerto Rico [21] | 164 | 164 | na | na | na | 7 (4.3) | 157 (95.7) | 1 (0.06) | na | 6 (3.7) | na | na | 1 (0.6) | na |
Lima, Peru [24] | 90 | 90 | na | na | na | 35 (38.9) | 55 (61.1) | 23 (25.6) | 18 (20) | 4 (4.4) | 2 (2.2) | na | 26 (28.9) | 64 (71.1) |
Rio Grande do Sul, Brazil [25] | 212 | 197 | 22 | 100 | 0 | 42 (21.3) | 155 (78.7) | na | na | na | na | na | 42 (21.4) | 155 (78.7) |
Mexico City, Mexico [27] | 10 | 6 | 0 | 5 | 1 | 2 (33.3) | 4 (66.7) | 2 (33.3) | na | 0 | na | na | na | na |
Minas Gerais, Brazil [28] | 77 | 77 | 10 | 17 | 10 | 16 (20.8) | 61 (79.2) | na | na | na | na | na | 16 (20.8) | 61 (79.2) |
Santiago, Chile [31] | 35 | 35 | 19 | 16 | na | 21 (60) | 14 (40) | 21 (60) | 0 | 6 (17.1) | 4 (11.4) | na | 28 (80) | 7 (20) |
Lambayeque, Peru [35] | 5 | 3 | 5 | 0 | na | 1 (33.3) | 2 (66.7) | 1 (33.3) | 1 (33.3) | 0 | 0 | na | 1 (33.3) | 0 |
Sao Paulo, Brazil [37] | 118 | 118 | 9 | 52 | 57 | 3 (2.5) | 115 (97.5) | 3 (2.5) | 3 (2.5) | 5 (4.2) | 5 (4.2) | na | 12 (10.2) | na |
Santo Andre, SP, Brazil [43] | 48 | 48 | 2 | na | 17 | 13 (27.1) | 35 (72.9) | 2 (4.2) | 3 (6.3) | 0 | 2 (4.2) | 9 (19) | na | na |
Lima, Peru [45] | 28 | 28 | 0 | 0 | 28 | 11 (39.3) | 17 (60.7) | na | na | na | na | na | 11 (39.3) | 17 (60.7) |
Total | 1042 | 1022 | 96 | 232 | 191 | 213 (20.8) | 809 (79.2) | 65 (46.4) | 25 (17.9) | 28 (20) | 13 (9.3) | 9 (6.4) | 168 (36.9) | 287 (63.1) |