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Table 2 Summary of published data from Latin America LS families

From: A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America

Latin America LS published databases Number of families Number of individuals Age at CRC diagnosis (mean ± SD) Age at endometrial cancer diagnosis (mean ± SD) AMSII Revised Bethesda Other criteria Path_MMR carriers (%) Path_MMR non- carriers (%) Path_MLH1 carriers (%) Path_MSH2 carriers (%) Path_MSH6 carriers (%) Path_PMS2 carriers (%) Path_EPCAM carriers (%)
Mendoza, Argentina [10] 1 17 na na 1 0 0 9(52.9) 8(47.1) 0 9100) na na na
Sao, Paulo, Brazil [11] 25 25 45.7(na) na 6 18 1 10(40) 15(60) 8(80) 2(20) na na na
Montevideo, Uruguay [13] 12 12 45 na 12 na na 3(25) 9(75) 2(67) 1(33) 0 na na
Bogota, Colombia [12, 48] 23 23 na na 11 12 na 11(47.8) 12(52.2) 10(91) 1(9) na na na
Buenos Aires, Argentina [17] 43 11 na na 43 0 na 5(45.5) 6 (54.5) 2(40) 3(60) na na na
Mexico, El Salvador and Guatemala [51] 13 14 38.7(na) na 5 9 na 11(78.6) 3(21.4) 7(64) 4 (36) na na na
Santiago, Chile [20] 21 20 na na 14 7 na 9(45) 11(55) 6(30) 3(15) na na na
Antioquia, Colombia [23] 1 20 na na 1 na na 7(35) 13(65) 7(100) 0 na na na
Southeastern Brazil, Buenos Aires and Montevideo [26] 123 123 na na 57 66 na 34(27.6) 89(72.4) 20(59) 14(41) na na na
Santiago, Chile [31] 35 35 na na 19 16 na 21(60) 14(40) 14(67) 5(24) 2(9) na na
South America [32] 267 267    147 120 na 99(37.1) 168(62.9) 59(60) 40(40) na na na
Buenos Aires, Argentina 28 na 44.3(6.2) 46.3(5.5)           
Montevideo, Uruguay 25 na 35.1(7.6) 41.5(8.3)           
Santiago, Chile 50 na 35.7(10.7) 41.1(8.8)           
Barretos, Brazil) 23 na 39.4(13.8) 49.8(5.3)           
Colombia 13 na na na           
Southeastern Brazil 128 na 42.3(11.4) 48.8(2.4)           
Puerto Rico and Dominican Republic [36] 78 31 44.4(na) 44 (na) na na na 22(71) 9 (29) 8(36) 13(59) 1(5) na na
Southeastern Brazil [37] 116 116 42.4(na) 46 (na) 49 67 na 45(38.8) 71(61) 15(33) 25(56) 4(9) 1(2) na
Jalisco, Mexico [44] 3 5 37.7(na) na 3 0 na 5(100) 0 4(80) 1(20) na na na
South America [47] 243 243    na na na 98(40.3) 145 (56.7) 42(43) 45(46) 7(7) 2(2) 2(2)
Buenos Aires, Argentina 48 na 44(na) 45(na)           
Montevideo, Uruguay 16 na 42.3(na) 48.8(na)           
Santiago, Chile 27 na 41.3(na) 43.6(na)           
Barretos, Brazil) 23 na 39.4(na) 49.8(na)           
Colombia 13 na na na           
Southeastern Brazil 116 na 42.4(na) 46(na)           
Total 1514 962    368 315 1 389 (40.4) 573 (59.6) 204 (52.4) 166 (42.7) 14 (3.6) 3 (0.8) 2 (0.5)
  1. LS: Lynch syndrome; CRC: colorectal cancer; MMR: mismatch repair; SD: standard deviation; na: not applied; Path_MMR: Pathogenic (disease-causing) variant of an MMR gene; path_MLH1: pathogenic variant of the MLH1 gene; path_MSH2: pathogenic variant of the MSH2 gene; path_MSH6: pathogenic variant of the MSH6 gene; path_PMS2: pathogenic variant of the PMS2 gene
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