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Table 4 Multivariate survival analysis of combinatory LINE-1 methylation level and lymphatic embolus status and clinicopathological parameters with respect to overall survival

From: Tumoral LINE-1 hypomethylation is associated with poor survival of patients with intrahepatic cholangiocarcinoma

Parameters   Hazard ratio (95% C.I.) P-value
LINE-1 methylation /lymphatic emboli status    0.001
High/absent (n = 58) Reference  
Low/present (n = 28) 3.128 (1.523–6.424) 0.002
Low/absent (n = 44) 1.113 (0.460–2.695) 0.812
High/present (n = 42) 0.761 (0.237–2.443) 0.647
Gross type    0.073
Mass forming (n = 141) Reference  
Periductal infiltrative (n = 8) 0 0.972
Intraductal growth (n = 18) 0.141 (0.019–1.032) 0.054
Mixed (n = 5) 3.013 (0.885–10.254) 0.078
T staging    0.152
pT1 (n = 48) Reference  
pT2 (n = 52) 0.579 (0. 220–1.526) 0.270
pT3 (n = 47) 0.371 (0.124–1.114) 0.077
pT4 (n = 25) 0.233 (0.056–0.971) 0.046
N staging pN0 (n = 133)   
pN1 (n = 39) 2.456 (1.341–4.497) 0.004
Perineural invasion Absent (n = 118)   
Present (n = 54) 0.321 (0.147–0.699) 0.004
Differentiation    0.577
Well (n = 23) Reference  
Moderate (n = 94) 3.495 (0.332–36.809) 0.298
Poor (n = 55) 3.493 (0.328–37.217) 0.300