Low-dose aspirin use | Controls N = 10,000 n (%) | Cases N = 3033 n (%) | RR (95% CI)a | RR (95% CI)b |
---|---|---|---|---|
Recency | ||||
Non-use | 3557 (35.6) | 1247 (41.1) | 1.00 (−) | 1.00 (−) |
Current use | 4562 (45.6) | 1255 (41.4) | 0.80 (0.73–0.88) | 0.66 (0.60–0.73) |
Recent/past usec | 475 (4.8) | 158 (5.2) | 0.73 (0.64–0.84) | 0.78 (0.64–0.95) |
Daily dosed | ||||
75 mg | 4128 (41.3) | 1137 (37.5) | 0.78 (0.71–0.86) | 0.66 (0.60–0.73) |
150 mg | 402 (4.0) | 107 (3.5) | 0.75 (0.60–0.94) | 0.62 (0.50–0.78) |
300 mg | 32 (0.3) | 11 (0.4) | 0.97 (0.49–1.94) | 0.82 (0.41–1.64) |
Formulation | ||||
Plain | 3716 (37.2) | 1008 (33.2) | 0.77 (0.70–0.85) | 0.65 (0.59–0.72) |
Enteric coated | 846 (8.5) | 247 (8.1) | 0.83 (0.71–0.97) | 0.70 (0.59–0.82) |
Duration of use | ||||
< 1 year | 1430 (14.3) | 433 (14.3) | 0.86 (0.76–0.97) | 0.72 (0.63–0.82) |
1–5 years | 2370 (23.7) | 632 (20.8) | 0.76 (0.68–0.84) | 0.64 (0.57–0.72) |
≥ 5 years | 762 (7.6) | 190 (6.3) | 0.70 (0.59–0.84) | 0.61 (0.51–0.73) |