Skip to main content

Table 5 Summary of studies investigating the prognostic role of the neutrophil-lymphocyte ratio (NLR) in oropharyngeal cancer (OC)

From: Neutrophil-lymphocyte ratio complements volumetric staging as prognostic factor in patients treated with definitive radiotherapy for oropharyngeal cancer

Study Cohort and treatment NLR cut-off Results p16 status
Rachidi et al. [13] n = 543 HNSCC (170 OC), any treatment
(2000–2012)
4.39 (upper tertile) - Increased mortality for high NLR (HR = 2.39)
- NLR prognostic factor both in p16-pos. And neg. Pts.
- NLR significantly lower in p16-pos. Patients
yes (89/543)
Charles et al. [29] n = 145 (76 OC), radio(chemo)therapy
(2005–2012)
5.0 (based on review [39]) - High NLR associated in OC with inferior OS (HR = 4.6) and RFS (HR = 3.01)
- No subgroup analysis for p16 pos. Pts.
yes (95/145)
Kano et al. [40] n = 285 HNSCC (116 OC), radiochemotherapy (2003–2012) 1.92 (based on ROC analysis) - High NLR associated with inferior OS and DFS, but not significant on multivariate analysis no
Valero et al. [35] n = 824 (203 OC), any treatment
(2010–2012)
1.35 and 3.86 (three groups based on RPA) - High NLR associated with inferior DSS
- Lower neutrophil number in p16 pos. Pts.
yes (125/824)
Selzer et al. [14] n = 170 (74 OC), primary radio(chemo)therapy or radioimmunotherapy
(2002–2012)
5.0 - High NLR associated with inferior median OS (17 vs. 27 months) no
Moon et al. [41] n = 153 (51 OC), HNSCC prospective study
(2010–2012)
not described - High NLR associated with inferior PFS (HR = 2.20) and OS (HR = 3.22) no
Huang et al. [34] n = 510, OC, radio(chemo)therapy
(2000–2010)
not applied (neutrophils and lymphocytes were analyzed separately) - High neutrophils and low lymphocytes are associated with inferior prognosis
- Reduced neutrophil count and similar lymphocyte count in p16-pos. Pts.
yes (all)
Young et al. [42] n = 249, OC, radio(chemo)therapy
(2004–2010)
5.0 - High NLR associated with inferior locoregional control (HR = 2.072) no
  1. HNSCC squamous cell carcinoma of the head and neck, pts. patients, ROC receiver-operating characteristic, RPA recursive partitioning analysis, OS Overall survival, PFS progression-free survival, DFS disease-free survival, DSS disease-specific survival