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Table 4 The associations between EGFR gene copies and clinicopathological parameters in recurrent tumor (N = 41)

From: EGFR copy number alterations in primary tumors, metastatic lymph nodes, and recurrent and multiple primary tumors in oral cavity squamous cell carcinoma

 

EGFR Gene Copies Number

 
 

Disomy

[N (%)]

Polysomy

[N (%)]

Amplification

[N (%)]

p value

Subsites

 Local (n = 31)

22 (71.0)

4 (80.0)

5 (100.0)

0.643

 Regional (n = 3)

2 (6.5)

1 (20.0)

0 (0.0)

 

 Distant metastasis (n = 7)

7 (22.5)

0 (0.0)

0 (0.0)

 

Tumor status

 T nulla (n = 10)

9 (29.0)

1 (20.0)

0 (0.0)

0.644

 Earlyb (n = 30)

21 (67.7)

4 (80.0)

5 (100.0)

 

 Advancedc (n = 1)

1 (3.2)

0 (0.0)

0 (0.0)

 

Lymph node metastasis

 Yes (n = 12)

10 (32.3)

2 (40.0)

0 (0.0)

0.289

 No (n = 29)

21 (67.7)

3 (60.0)

5 (100.0)

 

Radiation therapy

 Yes (n = 29)

22 (71.0)

4 (80.0)

3 (60.0)

0.936

 No (n = 12)

9 (29.0)

1 (20.0)

2 (40.0)

 

Chemotherapy

 Yes (n = 7)

7 (22.6)

0 (0.0)

0 (0.0)

0.256

 No (n = 34)

24 (77.4)

5 (100.0)

5 (100.0)

 
  1. ano primary tumor recurrence, but with either lymph node or distant metastasis
  2. bEarly: T1/T2 lesions
  3. cAdvanced: T3/T4 lesions