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Table 2 EGFR gene amplification in primary cancer with recurrence, multiple primaries, and neck metastasis

From: EGFR copy number alterations in primary tumors, metastatic lymph nodes, and recurrent and multiple primary tumors in oral cavity squamous cell carcinoma

 

EGFR gene copies number

 

EGFR gene copies

Disomy

[n (%)]

Polysomy

[n(%)]

Amplification

[n (%)]

Discordance

P value

Recurrent tumor

 Disomy (n = 31)

24 (77.4)

4 (12.9)

3 (9.7)

14/41 (34.1%)

0.261

 Polysomy (n = 5)

5 (100.0)

0 (0.0)

0 (0.0)

 

0.510*

 Amplificaiton (n = 5)

2 (40.0)

2 (40.0)

1 (20.0)

  

Second primary tumor

 Disomy (n = 12)

11 (91.7)

1 (8.3)

0 (0.0)

5/17 (29.4%)

0.264

 Polysomy (n = 3)

2 (66.7)

1 (33.3)

0 (0.0)

 

*NA

 Amplificaiton (n = 2)

1 (50.0)

1 (50.0)

0 (0.0)

  

Lymph node metastasis

 Disomy (n = 34)

25 (73.5)

2 (5.9)

7 (20.6)

18/57 (31.6%)

<0.001

 Polysomy (n = 9)

3 (33.3)

4 (44.4)

2 (22.2)

 

*0.389

 Amplificaiton (n = 14)

4 (28.6)

0 (0.0)

10 (71.4)

  
  1. *McNemar test