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Table 1 Studies investigating immune cell response and effect on prognosis in epithelial ovarian cancer

From: Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer

Paper Study Sample size Type of immune infiltrate Conclusion Effect on prognosis
Woo, E.Y. et al., 2001 [4] Immunohistochemistry and flow cytometric analysis 9 CD4(+)CD25(+) T cells CD8(+)CD25(+) T cells Increased % of CD4(+)CD25(+) T cells present in ovarian cancer. CD8(+) T cells expressed low levels of CD25 Not discussed
Zhang et al., 2003 [5] Immunohistochemistry 186 CD3(+) T cells The presence of intratumoral T cells correlated with delayed recurrence and an increased expression of IFN γ, IL-2, within the tumor. The absence of intratumoral T cells was associated with increased levels of VEGF. Increased CD3(+) T cells is associated with increased survival
Curiel, T.J., et al., 2004 [6] Immunohistochemistry 104 CD4(+)CD25(+)FOXP3(+) T(reg) cells T(reg) cells suppress tumor-specific T cell immunity and contribute to growth of human tumors in vivo. T(reg) cells are associated with a high death hazard and reduced survival T(reg) cells are associated with reduced survival
Sato, E., et al., 2005 [7] Immunohistochemistry 117 CD8(+) T cells CD3(+) T cells CD8(+)/CD4(+) T cell ratio Increased CD8+ T cells is associated with increased survival No association between CD3+ TILs and survival Increased CD8(+):CD4(+) associated with better survival Increased CD8+ T cells is associated with increased survival No association between CD3+ TILs and survival Increased CD8(+):CD4(+) associated with increased survival
Hamanishi, J., et al., 2007 [8] Immunohistochemistry 70 PD-L1 expression on tumour cells CD8(+) T cells Increased PD-L1 expression on tumour cells is associated with decreased CD8(+) T cells and decreased survival Increased CD8(+) t cells is independently associated with increased survival Increased CD8(+) t cells is associated with increased survival
Tomsova et al., 2007 Immunohistochemistry 116 CD3(+) T cells CD3(+) TILs are associated with increased survival Increased CD3(+) T cells is associated with increased survival
Shah, C.A., et al., 2008 [10] Immunohistochemistry 119 CD3(+) T cells CD8(+) T cells CD68(+) TAMs FoxP3(+) Tregs TIL and TAM levels are positively correlated Patients with greater TILs are more likely to be optimally cytoreduced The presence of circulating tumor DNA does not correlate with TILs, TAMs, or Tregs No association between any cell type and survival seen No association between any cell type and survival seen
Adams, S.F., et al., 2009 [11] Immunohistochemistry 134 CD3(+) T cells CD8(+) T cells FoxP3(+) Tregs Increased CD8(+) T cells is associated with increased survival No difference in survival associated with the other cell types Increased CD8(+) T cells is associated with increased survival No difference in survival associated with the other cell types
Clarke, B., et al., 2009 [12] Immunohistochemistry 500 CD8(+) T cells CD3(+) T cells Increased CD8(+) T cells is associated with increased survival Increased CD3(+) T cells is not associated with any difference in survival On subgroup analysis: For serous ovarian carcinomas, increased CD3(+) and CD8(+) T-cells correlated with improved survival For endometrioid and clear cell carcinomas there is no association between CD3(+) or CD8(+) and survival Increased CD8(+) T cells is associated with increased survival Increased CD3(+) T cells is not associated with any difference in survival
Leffers et al., 2009 [13] Immunohistochemistry 306 CD8(+) T cells CD45RO(+) Tmems FoxP3(+) Tregs increased CD8(+) CTL and CD8(+)/FoxP3(+) ratio is associated with increased survival in advanced stage patients increased CD8(+) T cells and FoxP3(+) Tregs is associated with increased survival increased CD8(+) CTL and CD8(+)/FoxP3(+) ratio is associated with increased survival in advanced stage patients increased CD8(+) T cells and FoxP3(+) Tregs is associated with increased survival
Stumpf et al., 2009 [14] Immunohistochemistry 100 CD20(+) B cells CD3(+) T cells CD4(+) T cells CD8(+) T cells CD3(+) T cells and CD8(+) T cells are associated with increased survival CD3(+) T cells and CD8(+) T cells are associated with increased survival
Webb et al., 2014 [15] Immunohistochemistry 497 CD103(+) T cells CD103(+) TILs comprise intraepithelial, activated CD8(+) T cells, and NK cells and are strongly associated with patient survival in HGSC CD103(+) TILs are strongly associated with patient survival in HGSC
Darb-Esfahani et al. 2016 [16] Immunohistochemistry 215 CD3+, PD-1+, and PD-L1+ T cells CD3+, PD-1+, and PD-L1+ TILs densities were correlated with increased survival Moreover, high PD-1+ TILs as well as PD-L1+ TILs densities added prognostic value to CD3 + TILs CD3+, PD-1+, and PD-L1+ TILs densities were correlated with increased survival in HGSC
Woulters et al. 2016 [17] Immunohistochemistry 171 CD8(+) T cells CD27(+) T cells A prognostic benefit for patients with high intratumoral CD8(+) TIL was observed if primary surgery had resulted in a complete cytoreduction, optimal or incomplete cytoreduction fully abrogated the prognostic effect of CD8(+) TIL. Neither CD8(+) nor CD27(+) cell infiltration was of prognostic benefit in patients treated with neoadjuvant chemotherapy. CD8+ TILs interact with treatment to affect prognosis
Bösmüller et al. 2016 [18] Immunohistochemistry 135 CD3 T cells CD103 T cells Both the presence of CD103 cells, as well as high numbers of intraepithelial CD3 lymphocytes (CD3E), showed a significant correlation with overall survival Both the presence of CD103 cells, as well as high numbers of intraepithelial CD3 lymphocytes (CD3E), showed a significant correlation with overall survival
Strickland et al. 2016 [19] Immunohistochemistry 245 CD3+ T cells CD8+ T cells Increased CD3+ and CD8+ TILs associated with increased survival Increased CD3+ and CD8+ TILs associated with increased survival
Kroeger et al. 2016 [20] immunohistochemistry   CD20+ Tcells CD4+ Tcells CD8+ T cells Plasma cells CD8(+) TIL carried prognostic benefit only in the presence of PCs and these other TIL subsets. CD8(+) TIL carried prognostic benefit only in the presence of PCs and these other TIL subsets.
  1. Table abbreviations: Tregs regulatory T cells, TAM tissue associated macrophages, Tmems memory T cells