Fig. 4

SKLB1002 inhibited in vivo tumor growth in HCT116 xenograft mouse model and decreased VE-cadherin expression in tumor tissues. a Photographs illustrating mice tumors derived from HCT116 cells with or without SKLB1002 treatment 30 days after inoculation. b The volume of the mice tumors derived from HCT116 cells was evaluated at 5-day intervals for 30 days. Data are shown as mean ± SD. c Hematoxylin & eosin staining photographs illustrating necrosis in mice tumor tissues derived from HCT116 cells with or without SKLB1002 treatment 30 days after inoculation (left). (×40). Quantitative analysis of the proportions of non-necrotic tissue in the largest section of tumor masses is shown as mean ± SD (right). d Expressions of VE-cadherin in mice tumor tissues derived from HCT116 cells with or without SKLB1002 treatment 30 days after inoculation were determined by immunohistochemical staining. (×400)