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Table 1 The association of miRNA-148a, miRNA-625-3p and tumor budding with clinical and pathological characteristics

From: Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding

Characteristic N miRNA 148-a expression miRNA 625-3p expression Tumor budding
   Low High p Low High p Yes No p
Total 54 27 27   27 27   21 33  
Age
 < 65 28 17 12 0.172 15 13 0.586 14 15 0.128
 ≥ 65 26 10 15 12 14 7 18
Gender
 Female 26 13 13 1.000 13 13 1.000 12 14 0.291
 Male 28 14 14 14 14 9 19
Location
 C18–19 34 15 19 0.260 13 21 0.024 11 23 0.199
 C20 20 12 8 14 6 10 10
Side
 Right 12 6 6 1.000 5 7 0.513 7 5 0.117
 Left 42 21 21 22 20 14 28
T
 1–3 36 17 19 0.564 16 20 0.248 14 22 1.000
 4 18 10 8 11 7 7 11
N
 0–1 34 15 19 0.260 16 18 0.573 11 23 0.199
 2 20 12 8 11 9 10 10
Extrahepatic metastases
 Yes 33 15 19 0.260 15 18 0.402 14 19 0.402
 No 21 12 8 12 9 7 14
Number of metastatic sites
 1–2 39 20 19 0.762 22 17 0.129 15 24 0.917
 ≥ 3 15 7 8 5 10 6 9
Type of adenocarcinoma
 Adenocarcinoma 43 24 19 0.091 24 19 0.311 18 25 0.376
 Mucinous 11 3 8 4 7 3 8
Tumor budding
 Yes 21 14 7 0.051 14 7 0.051 - - -
 No 33 13 20 13 20 - -
KRAS
 Mutated 37 18 19 0.770 17 20 0.379 15 22 0.713
 Wild type 17 9 8 10 7 6 11