From: Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding
Characteristic | N | miRNA 148-a expression | miRNA 625-3p expression | Tumor budding | ||||||
---|---|---|---|---|---|---|---|---|---|---|
 |  | Low | High | p | Low | High | p | Yes | No | p |
Total | 54 | 27 | 27 | Â | 27 | 27 | Â | 21 | 33 | Â |
Age | ||||||||||
 < 65 | 28 | 17 | 12 | 0.172 | 15 | 13 | 0.586 | 14 | 15 | 0.128 |
 ≥ 65 | 26 | 10 | 15 | 12 | 14 | 7 | 18 | |||
Gender | ||||||||||
 Female | 26 | 13 | 13 | 1.000 | 13 | 13 | 1.000 | 12 | 14 | 0.291 |
 Male | 28 | 14 | 14 | 14 | 14 | 9 | 19 | |||
Location | ||||||||||
 C18–19 | 34 | 15 | 19 | 0.260 | 13 | 21 | 0.024 | 11 | 23 | 0.199 |
 C20 | 20 | 12 | 8 | 14 | 6 | 10 | 10 | |||
Side | ||||||||||
 Right | 12 | 6 | 6 | 1.000 | 5 | 7 | 0.513 | 7 | 5 | 0.117 |
 Left | 42 | 21 | 21 | 22 | 20 | 14 | 28 | |||
T | ||||||||||
 1–3 | 36 | 17 | 19 | 0.564 | 16 | 20 | 0.248 | 14 | 22 | 1.000 |
 4 | 18 | 10 | 8 | 11 | 7 | 7 | 11 | |||
N | ||||||||||
 0–1 | 34 | 15 | 19 | 0.260 | 16 | 18 | 0.573 | 11 | 23 | 0.199 |
 2 | 20 | 12 | 8 | 11 | 9 | 10 | 10 | |||
Extrahepatic metastases | ||||||||||
 Yes | 33 | 15 | 19 | 0.260 | 15 | 18 | 0.402 | 14 | 19 | 0.402 |
 No | 21 | 12 | 8 | 12 | 9 | 7 | 14 | |||
Number of metastatic sites | ||||||||||
 1–2 | 39 | 20 | 19 | 0.762 | 22 | 17 | 0.129 | 15 | 24 | 0.917 |
 ≥ 3 | 15 | 7 | 8 | 5 | 10 | 6 | 9 | |||
Type of adenocarcinoma | ||||||||||
 Adenocarcinoma | 43 | 24 | 19 | 0.091 | 24 | 19 | 0.311 | 18 | 25 | 0.376 |
 Mucinous | 11 | 3 | 8 | 4 | 7 | 3 | 8 | |||
Tumor budding | ||||||||||
 Yes | 21 | 14 | 7 | 0.051 | 14 | 7 | 0.051 | - | - | - |
 No | 33 | 13 | 20 | 13 | 20 | - | - | |||
KRAS | ||||||||||
 Mutated | 37 | 18 | 19 | 0.770 | 17 | 20 | 0.379 | 15 | 22 | 0.713 |
 Wild type | 17 | 9 | 8 | 10 | 7 | 6 | 11 |