Is neuron-specific enolase useful for diagnosing malignant pleural effusions? evidence from a validation study and meta-analysis

Table 3 Clinical summary of included studies

First author	Year	Country	Cases/controls	Standard	Method	Cut-off value	TP	FP	FN	TN	QUADAS
Pettersson T	1988	Finland	31/22	Cytology, Histology	Radioimmunoassay	12.5μg/L	10	4	21	18	7
Shimokata K	1989	Japan	59/39	Cytology, Histology	EIA	26 ng/ml	11	2	48	37	8
Menard O	1993	France	24/18	Histology	Radioimmunoassay	8 ng/ml	13	2	11	16	8
San Jose ME	1997	Spain	88/183	Cytology, Histology	EIA	8.8μg/L	26	21	62	162	9
Miédougé M	1999	France	215/121	Cytology, Histology	EIA	18.1 ng/ml	39	3	176	118	10
Kuralay F	2000	Turkey	21/40	Histology	ELISA	8.7 ng/ml	21	2	0	38	9
Lee JH	2005	Korea	34/16	Histology	ELISA	20 ng/ml	12	1	22	15	10
Ghayumi SM	2005	Iran	40/37	Cytology, Histology	ELISA	5.21μg/ml	27	9	13	28	10
Topolcan O	2007	Czech Republic	80/78	Cytology, Histology	Immuno-radiometric assay	13.1 ng/ml	34	4	46	74	9
Wu GP	2007	China	74/34	Cytology, Histology	Immunoassay	5.2μg/L	51	15	23	19	9
Korczynski P	2009	Poland	36/38	Cytology, Histology	ECLIA	0.22 ng/ml	34	24	2	14	10
Wang Y	2013	China	160/40	Cytology, Histology	ECLIA	NA	95	15	65	25	11
Gu Y	2016	China	95/35	Histology	ECLIA	9.71 ng/ml	50	8	45	27	11
Zhu J	2016	China	136/102	Cytology, Histology	ECLIA	8.92 ng/ml	81	17	55	85	10

EIA Enzyme immunoassay, ECLIA Electrochemiluminescence immunoassay, ELISA Enzyme linked immunosorbent assay, FN false negative, FP false positive, NA Not available, QUADAS Quality Assessment of Diagnostic Accuracy Studies, TN true negative, TP true positive

ISSN: 1471-2407