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Table 3 Clinical summary of included studies

From: Is neuron-specific enolase useful for diagnosing malignant pleural effusions? evidence from a validation study and meta-analysis

First author Year Country Cases/controls Standard Method Cut-off value TP FP FN TN QUADAS
Pettersson T 1988 Finland 31/22 Cytology, Histology Radioimmunoassay 12.5μg/L 10 4 21 18 7
Shimokata K 1989 Japan 59/39 Cytology, Histology EIA 26 ng/ml 11 2 48 37 8
Menard O 1993 France 24/18 Histology Radioimmunoassay 8 ng/ml 13 2 11 16 8
San Jose ME 1997 Spain 88/183 Cytology, Histology EIA 8.8μg/L 26 21 62 162 9
Miédougé M 1999 France 215/121 Cytology, Histology EIA 18.1 ng/ml 39 3 176 118 10
Kuralay F 2000 Turkey 21/40 Histology ELISA 8.7 ng/ml 21 2 0 38 9
Lee JH 2005 Korea 34/16 Histology ELISA 20 ng/ml 12 1 22 15 10
Ghayumi SM 2005 Iran 40/37 Cytology, Histology ELISA 5.21μg/ml 27 9 13 28 10
Topolcan O 2007 Czech Republic 80/78 Cytology, Histology Immuno-radiometric assay 13.1 ng/ml 34 4 46 74 9
Wu GP 2007 China 74/34 Cytology, Histology Immunoassay 5.2μg/L 51 15 23 19 9
Korczynski P 2009 Poland 36/38 Cytology, Histology ECLIA 0.22 ng/ml 34 24 2 14 10
Wang Y 2013 China 160/40 Cytology, Histology ECLIA NA 95 15 65 25 11
Gu Y 2016 China 95/35 Histology ECLIA 9.71 ng/ml 50 8 45 27 11
Zhu J 2016 China 136/102 Cytology, Histology ECLIA 8.92 ng/ml 81 17 55 85 10
  1. EIA Enzyme immunoassay, ECLIA Electrochemiluminescence immunoassay, ELISA Enzyme linked immunosorbent assay, FN false negative, FP false positive, NA Not available, QUADAS Quality Assessment of Diagnostic Accuracy Studies, TN true negative, TP true positive