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Table 2 Diagnostic summary of NSE for malignant pleural effusion

From: Is neuron-specific enolase useful for diagnosing malignant pleural effusions? evidence from a validation study and meta-analysis

  MPE SCLC-MPE
  Serum NSE Pleural NSE Pleural/serum NSE ratio Serum NSE Pleural NSE Pleural/serum NSE ratio
Cut-off 12.29 ng/ml 8.92 ng/ml 0.39 12.29 ng/ml 17.42 ng/ml 0.60
Sensitivity 66.91% 59.56% 79.41% 100% 100% 100%
Specificity 62.75% 83.33% 57.84% 62.75% 92.16% 69.60%
AUC 0.65 0.76 0.68 0.86 0.99 0.92
  1. AUC Area under the curve, MPE Malignant pleural effusion, NSE Neuron-specific enolase, SCLC Small cell lung cancer