Fig. 4

Comparison of tumor volume doubling time in control arm, 2 mg T arm, and 5 mg T arm in the first month after the tumor appeared and the serum T levels were manipulated. The serum T level in mice of the control arm maintained an average of 1 ng/ml throughout the month (Fig. 1) and the tumor volume doubling time became longer in the second 15 days than that in the first 15 days (a). The serum T levels in the 2 mg T arm were higher than 3.5 ng/ml in the first 15 days and then declined to lower than 2 ng/ml in the second 15 days. The serum T levels in the 5 mg T arm were higher than 7 ng/ml in the first 15 days and then declined to 4 ng/ml in the second 15 days (Fig. 1). The tumor volume doubling time became shorter in the second 15 days compared to the first 15 days in both 2 mg and 5 mg T arms (b and c)