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Table 1 Correlation analysis of clinicopathological findings and biomarker expression

From: Urokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR): tumor expression patterns and prognostic value in oral cancer

Variable

 

Total N (%)

Low uPAR N (%)

High uPAR N (%)

P-value

Low TF N (%)

High TF N (%)

P-value

Low EGFR N (%)

High EGFR N (%)

P-value

Gender

Men

126 (66)

94 (69)

32 (59)

 

73 (63)

53 (70)

 

71 (62)

55 (71)

 

Women

65 (34)

43 (31)

22 (41)

0.219

42 (37)

23 (30)

0.372

43 (38)

22 (29)

0.191

Ageb

−

−

−

−

0.121

−

−

0.059

−

−

0.190

Tobacco

Never

32 (17)

22 (16)

10 (19)

 

20 (17)

12 (16)

 

20 (18)

12 (16)

 

Ever

159 (83)

115 (84)

44 (81)

0.682

95 (83)

64 (84)

0.772

94 (82)

65 (84)

0.722

Lowc

46 (24)

32 (23)

14 (26)

 

30 (26)

16 (21)

 

27 (24)

19 (25)

 

High

145 (76)

105 (77)

40 (74)

0.709

85 (74)

60 (79)

0.426

87 (76)

58 (75)

0.875

T-site

Tongue

93 (49)

69 (50)

24 (44)

 

48 (42)

45 (59)

 

53 (46)

40 (52)

 

FOM

98 (51)

68 (50)

30 (56)

0.461

67 (58)

31 (41)

0.018

61 (54)

37 (48)

0.459

Relapse

Yes

51 (27)

38 (28)

13 (24)

 

23 (20)

28 (37)

 

33 (29)

18 (23)

 

No

140 (73)

99 (72)

41 (76)

0.455

92 (80)

48 (63)

0.010

81 (71)

59 (77)

0.393

T-site

24 (38)

19 (44)

5 (25)

 

13 (39)

11 (37)

 

7 (39)

17 (38)

 

N-site

27 (43)

19 (44)

8 (40)

 

10 (30)

17 (57)

 

9 (50)

18 (40)

 

Both

12 (19)

5 (12)

7 (35)

0.071

10 (30)

2 (7)

0.028

2 (11)

10 (22)

0.566

Margins

Negative

107 (56)

77 (56)

30 (56)

 

66 (57)

41 (54)

 

63 (55)

44 (57)

 

Positive

84 (44)

60 (44)

24 (44)

0.935

49 (43)

35 (46)

0.639

51 (45)

33 (43)

0.798

T-stage

T1-T2

164 (86)

119 (87)

45 (83)

 

96 (83)

68 (89)

 

97 (85)

67 (87)

 

T3-T4

27 (14)

18 (13)

9 (17)

0.529

19 (17)

8 (11)

0.244

17 (15)

10 (13)

0.708

N-stage

N0

131 (69)

98 (72)

33 (61)

 

80 (70)

51 (67)

 

77 (68)

54 (70)

 

N+

60 (31)

39 (28)

21 (39)

0.162

35 (30)

25 (33)

0.720

37 (32)

23 (30)

0.706

ECS

Yes

16 (8)

10 (7)

6 (11)

 

10 (9)

6 (8)

 

11 (10)

5 (6)

 

No

175 (92)

127 (93)

48 (89)

0.395a

105 (91)

70 (92)

0.845

103 (90)

72 (94)

0.440

TNM Stage

S1-S2

136 (71)

104 (76)

32 (59)

 

81 (70)

55 (72)

 

82 (72)

54 (70)

 

S3-S4

55 (29)

33 (24)

22 (41)

0.022

34 (30)

21 (28)

0.773

32 (28)

23 (30)

0.788

Grade

G1-G2

171 (90)

121 (88)

50 (93)

 

105 (91)

66 (87)

 

103 (90)

68 (88)

 

G3-G4

20 (11)

16 (12)

4 (7)

0.385

10 (9)

10 (13)

0.324

11 (10)

9 (12)

0.652

G1

37 (19)

26 (19)

11 (20)

 

23 (20)

14 (18)

 

24 (21)

13 (17)

 

G2

134 (70)

95 (69)

39 (72)

 

82 (71)

52 (68)

 

79 (69)

55 (71)

 

G3

20 (11)

16 (12)

4 (7)

 

10 (9)

10 (13)

 

11 (10)

9 (12)

 

G4

0(0)

0 (0)

0 (0)

0.684

0 (0)

0 (0)

0.612

0 (0)

0 (0)

0.732

  1. Chi-square test. aFisher’s exact test used because of small numbers. bAge was treated as a continuous variable and correlations was calculated with a Student t-test. cLow defined as <10 pack years. Significant p-values of 0.05 or less are presented in bold
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