Skip to main content

Table 2 Difference of means over time among study arms

From: The feasibility and benefit of a brief psychosocial intervention in addition to early palliative care in patients with advanced cancer to reduce depressive symptoms: a pilot randomized controlled clinical trial

   A B C p-values
n Mean observed change from baseline n Mean observed change from baseline n Mean observed change from baseline Time vs. arm Arm Time
PHQ-9 d45 18 1.17 (5.71) 21 1.9 (5.03) 19 −0.53 (4.44) 0.497 0.780 0.029
d90 14 0.21 (4.89) 19 1.95 (5.86) 18 0.94 (4.12)    
d120 14 2.86 (6.7) 16 3.12 (6.09) 17 −0.76 (5.87)    
d180 12 2 (7.59) 12 3.83 (4) 14 2.07 (3.69)    
HADS-Anxiety d45 18 1.56 (3.09) 21 1.9 (3.91) 19 0.89 (4.37) 0.659 0.771 <0.001
d90 14 1.64 (4.05) 19 1 (4.88) 17 1.24 (5.66)    
d120 13 2.31 (2.93) 16 2.87 (3.26) 16 1.13 (5.12)    
d180 12 1.25 (3.89) 11 3.18 (2.79) 14 3.50 (3.16)    
HADS-Depression d45 17 0.65 (3.12) 21 2.05 (3.73) 19 2.11 (3.73) 0.188 0.854 0.017
d90 14 −0.43 (3.41) 19 1.11 (5.02) 18 2.44 (3.65)    
d120 14 0 (2.69) 16 2.69 (4.74) 17 1.12 (4.77)    
d180 12 −1.08 (4.46) 12 1.83 (4.06) 14 2.79 (4.04)    
ESAS- Anxiety d45 18 2.11 (3.5) 21 1.48 (2.52) 19 0.95 (3.42) 0.687 0.966 <0.001
d90 14 1.71 (2.46) 19 1.58 (3.95) 18 1.17 (3.33)    
d120 14 2.93 (3.17) 16 2.13 (2.68) 17 0.59 (4.06)    
d180 12 2.92 (3.20) 12 2.42 (2.43) 14 1.36 (3.20)    
ESAS-Depression d45 18 0.11 (3.01) 21 0.48 (1.89) 19 0.37 (1.3) 0.393 0.650 0.520
d90 14 0.21 (3.75) 19 0.42 (1.68) 18 0.06 (2.88)    
d120 14 0.57 (2.31) 16 0.25 (1.73) 17 −0.82 (3)    
d180 12 0.25 (2.09) 12 0.42 (1) 14 0.43 (1.91)    
ESAS- Emotional domain d45 18 2 (4.17) 21 1.95 (3.07) 19 1.32 (4.57) 0.516 0.825 0.001
d90 14 1.93 (5) 19 1.16 (4.54) 18 1.22 (5.77)    
d120 14 3.5 (3.98) 16 2.38 (3.59) 17 0.24 (6.69)    
d180 12 3.17 (2.55) 12 2.83 (2.72) 14 1.79 (4.69)    
EORTC QLQC-15Pal Total d45 17 −5.88 (18.58) 21 −7.14 (24.48) 19 −15.79 (32.62) 0.276 0.626 0.023
d90 14 4.76 (23.96) 19 −7.02 (16.02) 18 −12.04 (21.24)    
d120 14 −2.38 (22.51) 16 −4.17 (28.87) 17 −16.67 (30.05)    
d180 12 0 (22.47) 12 2.78 (35.41) 14 −20.24 (27.09)    
EORTC QLQC-15Pal Emotional domain d45 18 −17.59 (29.96) 21 −8.73 (21.49) 19 −7.89 (28.53) 0.352 0.877 0.005
d90 14 −20.24 (29.37) 19 −3.51 (21.93) 18 −3.70 (26.54)    
d120 14 −22.62 (26.64) 16 −8.33 (29.81) 17 3.92 (36.1)    
d180 12 −16.67 (30.15) 12 −15.28 (15.01) 14 −9.52 (38.52)