Table 8 Subgroup analysis based on different dose schedule of cisplatin to compare the toxicities of CCRT and CCRT with cetuximab
Toxic effects received weekly cisplatin, No. (%) | p value* | |||||
CCRT +Cetuximab(n = 23) | CCRT alone(n = 60) | |||||
All Grades | Grade3 ~ 4 | All Grades | Grade3 ~ 4 | All Grades | Grade3 ~ 4 | |
Leucopenia | 14 | 4 | 49 | 11 | 0.047 | 1 |
Neutropenia | 13 | 2 | 32 | 5 | 0.794 | 1 |
Anaemia | 4 | 1 | 36 | 1 | 0.001 | 0.48 |
Thrombocytopenia | 3 | 1 | 20 | 3 | 0.065 | 1 |
AST increased | 3 | 0 | 10 | 0 | 0.945 | — |
ALT increased | 15 | 1 | 17 | 1 | 0.002 | 0.48 |
BUN | 0 | 0 | 4 | 0 | 0.486 | — |
CRE | 0 | 0 | 0 | 0 | — | — |
Mucositis | 23 | 7 | 58 | 13 | 0.931 | 0.403 |
Dermatitis | 17 | 1 | 50 | 4 | 0.507 | 1 |
Vomiting | 17 | 2 | 24 | 0 | 0.006 | 0.074 |
Weight loss | 20 | 1 | 54 | 0 | 0.996 | 0.277 |
Toxic effects received triweekly cisplatin, No. (%) | p value* | |||||
CCRT +Cetuximab(n = 39) | CCRT alone(n = 64) | |||||
All Grades | Grade3 ~ 4 | All Grades | Grade3 ~ 4 | All Grades | Grade3 ~ 4 | |
Leucopenia | 28 | 4 | 54 | 8 | 0.124 | 0.978 |
Neutropenia | 21 | 2 | 37 | 4 | 0.694 | 1 |
Anaemia | 6 | 1 | 33 | 1 | < 0.001 | 1 |
Thrombocytopenia | 6 | 0 | 14 | 2 | 0.419 | 0.525 |
AST increased | 7 | 0 | 10 | 0 | 0.758 | — |
ALT increased | 21 | 0 | 18 | 1 | 0.009 | 1 |
BUN | 3 | 0 | 6 | 0 | 1 | — |
CRE | 2 | 0 | 13 | 0 | 0.034 | — |
Mucositis | 39 | 25 | 61 | 16 | 0.442 | < 0.001 |
Dermatitis | 37 | 2 | 54 | 1 | 0.196 | 0.66 |
Vomiting | 32 | 1 | 42 | 2 | 0.072 | 1 |
Weight loss | 37 | 1 | 51 | 0 | 0.034 | 0.379 |