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Table 4 Effect modification of association between active smoking and breast cancer in 21,831 women in the Danish Nurse Cohort by menopausal status, obesity, alcohol consumption and hormone therapy use

From: Active smoking and risk of breast cancer in a Danish nurse cohort study

   

Never

Former

Current

Ever

N

No. of cases

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

Menopausal status

 Premenopausal

9455

466

1.00

1.03 (0.82–1.29)

1.30 (1.04–1.61)

1.16 (0.95–1.40)

 Postmenopausal

12,376

696

1.00

1.12 (1.92–1.37)

1.27 (1.05–1.52)

1.20 (1.02–1.42)

p-value

    

0.77

0.80

BMI

 Not obese (< 30 kg/m2)

20,578

1086

1.00

1.07 (0.92–1.25)

1.25 (1.08–1.45)

1.11 (1.03–1.33)

 Obese (≥ 30 kg/m2)

1253

76

1.00

1.23 (0.72–2.09)

1.47 (0.81–2.66)

1.32 (0.82–2.12)

p-value

    

0.84

0.63

Alcohol Consumption

 None

3320

183

1.00

1.11 (0.77–1.61)

1.17 (0.83–1.66)

1.14 (0.85–1.54)

 Moderate (1–14 drinks/week)

13,533

670

1.00

1.13 (0.94–1.37)

1.26 (1.05–1.52)

1.19 (1.02–1.40)

 Heavy (>14 drinks/week)

4978

309

1.00

0.96 (0.70–1.31)

1.34 (1.01–1.77)

1.17 (0.90–1.52)

p-value

    

0.66

0.99

Hormone therapy use

 Never

15,880

755

1.00

1.05 (0.88–1.26)

1.21 (1.02–1.44)

1.13 (0.97–1.32)

 Ever

5951

407

1.00

1.15 (0.88–1.49)

1.36 (1.06–1.73)

1 26 (1.01–1.58)

p-value

    

0.63

0 33