Table 4 EORTC QLQ-C30 scores during first-line chemotherapy and during MT
| Â | 1st Line | Maintenance | Â | Â | Â | Â | ||
|---|---|---|---|---|---|---|---|---|
| Â | Mean | 95% CI | Mean | 95% CI | Diff. | 95% CI | F-value | p-value |
Physical Functioning | 73.5 | 70.7-76.3 | 73.8 | 69.1-78.6 | −0.3 | −5.8-5.2 | 0.014 | 0.906 |
Role Functioning | 62.4 | 58.5-66.2 | 59.1 | 53.0-65.1 | 3.3 | −3.9-10.4 | 0.817 | 0.367 |
Social Functioning | 66.2 | 62.8-69.7 | 70.5 | 64.9-76.0 | −4.2 | −10.7-2.3 | 1.630 | 0.203 |
Emotional Functioning | 65.0 | 62.1-67.9 | 68.9 | 64.0-73.7 | −3.9 | −9.5-1.8 | 1.826 | 0.178 |
Cognitive Functioning | 80.0 | 77.4-82.6 | 82.8 | 78.5-87.1 | −2.8 | −7.8-2.2 | 1.194 | 0.276 |
Global Quality of Life | 58.2 | 55.7-60.8 | 57.3 | 53.1-61.4 | 1.0 | −3.9-5.8 | 0.156 | 0.693 |
Fatigue | 45.8 | 42.4-49.2 | 41.2 | 35.7-46.8 | 4.6 | −1.9-11.1 | 1.949 | 0.164 |
Nausea/Vomiting | 13.5 | 11.0-16.0 | 8.2 | 5.3-11.1 | 5.3 | 1.5-9.1 | 7.663 | 0.006 |
Pain | 27.0 | 23.6-30.3 | 24.4 | 18.8-30.0 | 2.6 | −3.9-9.1 | 0.612 | 0.435 |
Dyspnea | 29.6 | 25.8-33.3 | 35.9 | 29.9-42.0 | −6.4 | −13.4-0.7 | 3.202 | 0.076 |
Sleep Disturbances | 39.1 | 35.1-43.2 | 21.4 | 15.7-27.1 | 17.8 | 10.8-24.7 | 25.480 | <0.001 |
Appetite Loss | 26.1 | 22.2-29.9 | 18.6 | 12.5-24.7 | 7.5 | 0.2-14.7 | 4.172 | 0.043 |
Constipation | 17.3 | 13.9-20.6 | 10.5 | 6.2-14.9 | 6.7 | 1.2-12.2 | 5.862 | 0.017 |
Diarrhea | 7.8 | 5.4-10.3 | 6.1 | 2.5-9.7 | 1.7 | −2.6-6.1 | 0.627 | 0.430 |
Financial Impact | 19.6 | 16.3-23.0 | 23.6 | 17.9-29.3 | −4.0 | −10.6-2.6 | 1.426 | 0.234 |
QLQ-C30 Summary Score | 71.8 | 69.7-73.9 | 75.7 | 72.4-79.0 | −3.9 | −7.9-0.0 | 3.948 | 0.048 |