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Table 4 EORTC QLQ-C30 scores during first-line chemotherapy and during MT

From: Clinical decision-making and health-related quality of life during first-line and maintenance therapy in patients with advanced non-small cell lung cancer (NSCLC): findings from a real-world setting

  1st Line Maintenance     
  Mean 95% CI Mean 95% CI Diff. 95% CI F-value p-value
Physical Functioning 73.5 70.7-76.3 73.8 69.1-78.6 −0.3 −5.8-5.2 0.014 0.906
Role Functioning 62.4 58.5-66.2 59.1 53.0-65.1 3.3 −3.9-10.4 0.817 0.367
Social Functioning 66.2 62.8-69.7 70.5 64.9-76.0 −4.2 −10.7-2.3 1.630 0.203
Emotional Functioning 65.0 62.1-67.9 68.9 64.0-73.7 −3.9 −9.5-1.8 1.826 0.178
Cognitive Functioning 80.0 77.4-82.6 82.8 78.5-87.1 −2.8 −7.8-2.2 1.194 0.276
Global Quality of Life 58.2 55.7-60.8 57.3 53.1-61.4 1.0 −3.9-5.8 0.156 0.693
Fatigue 45.8 42.4-49.2 41.2 35.7-46.8 4.6 −1.9-11.1 1.949 0.164
Nausea/Vomiting 13.5 11.0-16.0 8.2 5.3-11.1 5.3 1.5-9.1 7.663 0.006
Pain 27.0 23.6-30.3 24.4 18.8-30.0 2.6 −3.9-9.1 0.612 0.435
Dyspnea 29.6 25.8-33.3 35.9 29.9-42.0 −6.4 −13.4-0.7 3.202 0.076
Sleep Disturbances 39.1 35.1-43.2 21.4 15.7-27.1 17.8 10.8-24.7 25.480 <0.001
Appetite Loss 26.1 22.2-29.9 18.6 12.5-24.7 7.5 0.2-14.7 4.172 0.043
Constipation 17.3 13.9-20.6 10.5 6.2-14.9 6.7 1.2-12.2 5.862 0.017
Diarrhea 7.8 5.4-10.3 6.1 2.5-9.7 1.7 −2.6-6.1 0.627 0.430
Financial Impact 19.6 16.3-23.0 23.6 17.9-29.3 −4.0 −10.6-2.6 1.426 0.234
QLQ-C30 Summary Score 71.8 69.7-73.9 75.7 72.4-79.0 −3.9 −7.9-0.0 3.948 0.048
  1. 95% CI 95% confidence interval; Bold type indicates p <.05