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Table 3 Univariate and multivariate analysis of factors associated with survival in HCC patients (n = 174)

From: Down-regulation of the tumour suppressor κ-opioid receptor predicts poor prognosis in hepatocellular carcinoma patients

  OS
Univariate analysis Multivariate analysis
HR 95% CI P HR 95% CI P
Gender (Female vs. Male) 0.755 0.415–1.374 0.354    
Age, years (≤ 50 vs. > 50) 1.382 0.878–2.177 0.159    
HBsAg (Negative vs. Positive) 2.922 1.067–8.003 0.028* 2.729 0.994–7.491 0.051
Child-Pugh classification (A vs. B) 1.669 0.609–4.577 0.320    
Serum AFP, ng/ml (≤ 20 vs. > 20) 1.133 0.689–1.863 0.62    
Tumor Number (Single vs. Multiple) 1.638 0.953–2.814 0.07    
Tumor size, cm (≤ 5 vs. > 5) 2.429 1.455–4.056 < 0.001* 1.888 1.121–3.179 0.017*
Tumor capsule (No/ incomplete vs. Yes) 0.662 0.421–1.042 0.072    
Vascular invasion (N0 vs. Yes) 2.126 0.976–4.634 0.051    
Liver cirrhosis (Absent vs. Present) 1.097 0.592–2.035 0.767    
Differentiation grade (I / II vs. III/IV) 1.348 0.856–2.125 0.194    
TNM stage (I vs. II/III) 1.968 1.222–3.171 0.004* 1.558 0.961–2.528 0.072
KOR (Positive vs. Negative) 0.499 0.387–0.642 < 0.001* 0.526 0.408–0.679 < 0.001*
  1. P-values were obtained from the Cox proportional hazards regression analysis
  2. *Statistical significance was set to P < 0.05