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Table 1 Correlation of KOR mRNA expression with clinicopathological features in HCC (n = 64)

From: Down-regulation of the tumour suppressor κ-opioid receptor predicts poor prognosis in hepatocellular carcinoma patients

Variables Cases KOR mRNA
T < N (n = 51) T ≥ N (n = 13) P
Gender
 Female 8 5 3 0.196
 Male 56 46 10
Age, years
 ≤ 50 28 22 6 0.845
 > 50 36 29 7
HBsAg
 Negative 8 6 2 0.725
 Positive 56 45 11
Child-Pugh classificationa
 A 61 49 12 0.566
 B 3 2 1
Serum AFP, ng/ml
 ≤ 20 30 21 9 0.070
 > 20 34 30 4
Tumor Number
 Single 48 37 11 0.370
 Multiple 16 14 2
Tumor size, cm
 ≤ 5 35 24 11 0.015*
 > 5 29 27 2
Tumor capsule
 No/incomplete 31 23 8 0.290
 Yes 33 28 5
Vascular invasion
 No 58 46 12 0.816
 Yes 6 5 1
Liver cirrhosis
 Absent 11 7 4 0.146
 Present 53 44 9
Differentiation grade
 I / II 34 23 11 0.011*
 III/IV 30 28 2
TNM stage
 I 36 25 11 0.021*
 II/III 28 26 2
  1. The data are reported as number. P-values were obtained from the chi-square test. aNo patient with Child-Pugh class C was found. *Statistical significance was set to P < 0.05