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Table 2 Analysis of risk factors for any positive ALNs

From: Development of nomograms to predict axillary lymph node status in breast cancer patients

  Univariate analysis Multivariate analysis
  N0 N1–3 P b OR(95%) P
  n %a n %a
Age Group
 Age < =50Yrs 15,652 67.38 7579 32.62 <0.001 1  
 50-60Yrs 18,757 72.23 7210 27.77 0.91(0.87–0.95) <0.001
  > 60Yrs 39,253 77.85 11,167 22.15 0.70(0.67–0.73) <0.001
Location Of Lesions
 UIQ 15,519 82.15 3372 17.85 <0.001 1  
 UOQ 38,406 71.96 14,966 28.04 1.84(1.75–1.93) <0.001
 LOQ 8149 71.33 3276 28.67 1.91(1.79–2.03) <0.001
 LIQ 7089 78.02 1997 21.98 1.46(1.36–1.56) <0.001
 Central 4499 65.74 2345 34.26 2.19(2.03–2.35) <0.001
T-Stage
 T1 57,744 83.23 11,631 16.77 <0.001 1  
 T2 15,160 54.78 12,515 45.22 3.05(2.95–3.16) <0.001
 T3 758 29.52 1810 70.48 7.85(7.12–8.65) <0.001
Histology
 IDC 55,824 73.48 20,150 26.52 <0.001 1  
 ILC 6174 71.94 2408 28.06 1.08(1.02–1.15) 0.009
 IDC & ILC 3437 68.67 1568 31.33 1.19(1.11–1.28) <0.001
 IDC & Others 2688 80.02 671 19.98 0.74(0.67–0.82) <0.001
 IMC 1731 93.62 118 6.38 0.24(0.19–0.29) <0.001
 Others 3808 78.53 1041 21.47 0.79(0.73–0.86) <0.001
Grade
 I 21,746 84.74 3917 15.26 <0.001 1  
 II 32,129 73.17 11,779 26.83 1.29(1.23–1.35) <0.001
 III 19,337 65.73 10,083 34.27 1.31(1.24–1.38) <0.001
 Others/NA 450 71.77 177 28.23 1.27(1.04–1.56) 0.022
Estrogen Receptor
 Negative 11,326 71.93 4420 28.07 <0.001 1  
 Positive 62,336 74.32 21,536 25.68 1.20(1.12–1.28) <0.001
Progesterone Receptor
 Negative 18,233 72.70 6847 27.30 <0.001 1  
 Positive 55,429 74.36 19,109 25.64 1.16(1.10–1.23) <0.001
Her2
 Negative 65,656 74.89 22,014 25.11 <0.001 1  
 Positive 8006 67.01 3942 32.99 1.11(1.05–1.16) <0.001
Lymphovascular Invasion
 Not Present 66,799 82.82 13,858 17.18 <0.001 1  
 Present 6863 36.20 12,098 63.80 6.36(6.12–6.60) <0.001
  1. ALN axillary lymph node, Yrs years old, HER2 human epidermal growth factor receptor 2, LIQ lower-inner quadrant, LOQ lower-outer quadrant, UIQ Upper-inner quadrant, UOQ Upper-outer quadrant, N/A not available, IDC infiltrating ductal carcinoma, ILC infiltrating lobular carcinoma, IMC invasive mucinous carcinoma, NS non-significant
  2. aRow percentage was shown
  3. bChi-square test was used for univariate analysis